The proposed Heart Failure Regional Clinical Center (HF-RCC) application provides a unique opportunity to access practicing physicians as well as rural and minority outreach to support heart failure research and education. The network is an academic - community physicians partnership pioneered by the Morehouse School of Medicine Community Physicians'Network (CRN), to promote clinical research and practice based quality improvement. The network allows seamless integration of NIH supported clinical protocols at the community practice level. The HF RCC builds up on this model by bringing together the largest Cardiology group practice, in North Atlanta, known in the southeast USA for leading edge practice and research with 2 of the largest and oldest minority owned Cardiology practices in the South Metro Atlanta and surrounding rural communities. The extraordinary geographic reach of the network, its socioeconomic and ethnic diversity is evident from the Heart Failure Registry database, a summary of which is included with this application. Finally, the affiliations with St. Joseph's Hospital and Grady Hospital, large tertiary care centers, respectively known nationally for award winning cardiovascular care and outstanding care delivery to the underserved, provide unprecedented opportunity and credibility to impact cardiovascular care and health disparities. The longstanding mission of MSM to promote equitable care for all is the ultimate engine and passion that drives the network. Indeed participating practices and hospitals have cited this commitment as a key motivator for their interest in the Community Physicians'Network. We have proposed an infrastructure based on our experience and expertise in recruiting and retaining difficult to reach patient populations. The two projects provide an opportunity to fully exploit the intellectual and infrastructure capacity of the Network. Both projects capitalize on the size of the Heart Failure patient population in our RCC, as well as expertise of investigators. Project one draws upon our research interest in remodeling in hypertensive heart disease and heart failure, and also takes advantage of our group's interest in the role of NO in cardiac and vascular remodeling. The second project is largely based on the expertise of our collaborator, Nicholas Chronos, MD in cell based therapies in preclinical and early phase clinical trials. The proposed clinical skills development core integrates existing clinical training resource such as the successful Master of Science in Clinical Research Program at MSM and the sought after cardiovascular research training program at St. Joseph's Research Institute. In summary, we have proposed a very unique application which should serve as a model for future collaborative research networks that seek to actively engage and integrate community practices, a key stated goals of the NIH to map initiative.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL084891-04
Application #
7905706
Study Section
Special Emphasis Panel (ZHL1-CSR-H (M1))
Program Officer
Mascette, Alice
Project Start
2007-09-01
Project End
2012-12-31
Budget Start
2011-01-01
Budget End
2012-12-31
Support Year
4
Fiscal Year
2011
Total Cost
$340,000
Indirect Cost
Name
Morehouse School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
102005451
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Vader, Justin M; LaRue, Shane J; Stevens, Susanna R et al. (2016) Timing and Causes of Readmission After Acute Heart Failure Hospitalization-Insights From the Heart Failure Network Trials. J Card Fail 22:875-883
AbouEzzeddine, Omar F; Lala, Anuradha; Khazanie, Prateeti P et al. (2016) Evaluation of a provocative dyspnea severity score in acute heart failure. Am Heart J 172:34-41
Wan, Siu-Hin; Stevens, Susanna R; Borlaug, Barry A et al. (2016) Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure). Circ Heart Fail 9:
Butler, Javed; Hernandez, Adrian F; Anstrom, Kevin J et al. (2016) Rationale and Design of the ATHENA-HF Trial: Aldosterone Targeted Neurohormonal Combined With Natriuresis Therapy in Heart Failure. JACC Heart Fail 4:726-35
AbouEzzeddine, Omar F; Wong, Yee Weng; Mentz, Robert J et al. (2016) Evaluation of Novel Metrics of Symptom Relief in Acute Heart Failure: The Worst Symptom Score. J Card Fail 22:853-858
Hussain, Imad; Mohammed, Selma F; Forfia, Paul R et al. (2016) Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Circ Heart Fail 9:e002729
Redfield, Margaret M; Anstrom, Kevin J; Levine, James A et al. (2015) Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med 373:2314-24
AbouEzzeddine, Omar F; Haines, Phillip; Stevens, Susanna et al. (2015) Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). JACC Heart Fail 3:245-52
Givertz, Michael M; Anstrom, Kevin J; Redfield, Margaret M et al. (2015) Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. Circulation 131:1763-71
Zakeri, Rosita; Borlaug, Barry A; McNulty, Steven E et al. (2014) Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail 7:123-30

Showing the most recent 10 out of 25 publications