This proposal demonstrates the great potential of the University of Virginia (UVA) to make major contributions to the NHLBI/NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Together with our consortium institutions, Inova Fairfax Hospital and Carilion Roanoke Memorial Hospital, our team performs an average of 3,000 adult cardiovascular surgical procedures annually (>800 cases at UVA alone) which would be available for recruitment in Network protocols. The investigative group is led by Dr. Irving L. Kron, a cardiothoracic and vascular surgeon who is Chair of the Department of Surgery at UVA. He has been involved in multiple national leadership roles that relate to cardiothoracic research and education. He also has received long term research funding from NHLBI. The co-principal investigator is Dr. Karen C. Johnston, a nationally recognized vascular certified neurologist with NINDS funding and expertise in clinical trials, neuroprotection and outcomes research. Additionally, Dr. John Dent, a nationally known cardiologist, provides specific expertise in echocardiography as it applies to valvular heart disease. The unique mix of cardiovascular surgery, stroke neurology/neurological outcomes, and cardiology in addition to a large urban and rural population base guarantees that UVA will make substantive and novel contributions to the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine.
Our specific aims i nclude:
Specific Aim 1 : To describe the experience, expertise and collaborative nature of UVA that will substantially contribute to the success of a Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine.
Specific Aim 2 : To demonstrate the proof of concept for a subvalvular approach for ischemic mitral valve regurgitation by repositioning the posterior papillary muscle of the mitral valve in a phase II randomized clinical trial.
Specific Aim 3 : To demonstrate the efficacy and safety of perioperative Atorvastatin therapy for patients undergoing major cardiac surgery in a randomized, blinded, controlled phase III trial. Preliminary data have suggested that this intervention will reduce mortality and morbidity in cardiac surgical patients even without atherosclerosis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01HL088925-05S2
Application #
8657297
Study Section
Special Emphasis Panel (ZHL1-CSR-A (M1))
Program Officer
Miller, Marissa A
Project Start
2007-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$98,750
Indirect Cost
Name
University of Virginia
Department
Surgery
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Kron, Irving L; LaPar, Damien J; Horvath, Keith A et al. (2016) Cardiothoracic Surgical Trials Network: Evidence-based surgery. J Thorac Cardiovasc Surg 151:28-9
Mehaffey, James H; LaPar, Damien J; Tracci, Margret C et al. (2016) Modifiable Factors Leading to Increased Length of Stay after Carotid Endarterectomy. Ann Vasc Surg :
LaPar, Damien J; Acker, Michael A; Gelijns, Annetine C et al. (2015) Repair or replace for severe ischemic mitral regurgitation: prospective randomized multicenter data. Ann Cardiothorac Surg 4:411-6
Ghanta, Ravi K; Lapar, Damien J; Kern, John A et al. (2015) Minimally invasive aortic valve replacement provides equivalent outcomes at reduced cost compared with conventional aortic valve replacement: A real-world multi-institutional analysis. J Thorac Cardiovasc Surg 149:1060-5
LaPar, Damien J; Quader, Mohammed; Rich, Jeffrey B et al. (2015) Institutional Variation in Mortality After Stroke After Cardiac Surgery: An Opportunity for Improvement. Ann Thorac Surg 100:1276-82; discussion 1282-3
LaPar, Damien J; Ghanta, Ravi K; Kern, John A et al. (2014) Hospital variation in mortality from cardiac arrest after cardiac surgery: an opportunity for improvement? Ann Thorac Surg 98:534-9; discussion 539-40
LaPar, Damien J; Isbell, James M; Mulloy, Daniel P et al. (2014) Planned cardiac reexploration in the intensive care unit is a safe procedure. Ann Thorac Surg 98:1645-51; discussion 1651-2
LaPar, Damien J; Filardo, Giovanni; Crosby, Ivan K et al. (2014) The challenge of achieving 1% operative mortality for coronary artery bypass grafting: a multi-institution Society of Thoracic Surgeons Database analysis. J Thorac Cardiovasc Surg 148:2686-96
Horvath, Keith A; Acker, Michael A; Chang, Helena et al. (2013) Blood transfusion and infection after cardiac surgery. Ann Thorac Surg 95:2194-201
Mehta, Gaurav S; LaPar, Damien J; Bhamidipati, Castigliano M et al. (2012) Previous percutaneous coronary intervention increases morbidity after coronary artery bypass grafting. Surgery 152:5-11

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