Obesity represents a chronic disease associated with significant cardiovascular disease (CVD) morbidity and mortality. Weight gain in young adults adversely impacts the development of CVD risk factors. Further, there is a clear relationship between weight loss in obese persons and reduction in these CVD risk factors. Unfortunately, young adults are at high risk for weight gain. Although the scientific literature contains a number of reports regarding successful weight loss efficacy studies, young adults are typically underrepresented. Cigarette smoking is the leading preventable cause of morbidity and mortality, but quitting smoking results in significant weight gain. Tobacco quit lines have been shown to help persons quit smoking. However, concerns about post-cessation weight gain have been reported as a significant barrier to quitting. If an efficacious behavioral weight loss program could be combined with an efficacious behavioral smoking cessation program that prevented post-cessation weight gain, then a large public health benefit may result. Such a combined weight loss / smoking cessation program that used targeted intervention strategies to young adults, removed barriers to participation, and utilize interactive technology should be appealing to this age group. To date such a combined program has not been tested in young overweight and obese cigarette smokers trying to quit. Therefore, the objective of this clinical trial is to develop and test a behavioral weight loss intervention delivered through interactive technology that can be used in conjunction with an efficacious tobacco quit line (QL). A total of 330 participants will be necessary to adequately address the following specific aims: Primary Aim: We hypothesize that an efficacious proactive tobacco quit line plus a behavioral weight loss intervention delivered through interactive technology (Intervention Group) will significantly attenuate or prevent weight gain associated with smoking cessation at 2 years after enrollment compared to a proactive tobacco quit line alone (Comparison Group) in young overweight and obese smokers. Secondary Aims: We also plan to assess changes between the groups in: a.) Biochemically verified smoking cessation;b.) Diet and eating behavior;and c.) Physical activity.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL096628-04
Application #
8296227
Study Section
Special Emphasis Panel (ZHL1-CSR-R (M2))
Program Officer
Loria, Catherine
Project Start
2009-08-17
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$951,579
Indirect Cost
$308,620
Name
University of Tennessee Health Science Center
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163