The regeneration of human bone marrow from transplantation is now a common medical practice in the United States. Although stem cells resident in cardiac tissues and pulmonary tissues have been identified in humans, much remains to be learned about stem cell and progenitor cell biology in these tissues and in the bone marrow. A Consortium (the NHLBI Progenitor Cell Biology Consortium) could take advantage of recent developments (discoveries, technologies and reagents) to Identify and characterize progenitor cell lineages, to direct the differentiation of stem and progenitor cells and to address the challenges of transplanting those cells to translate into treatments in the regenerative biology and medicine armamentarium. An Administrative Coordinating Center (ACC) is necessary for this Consortium to achieve its goals of applying advances in stem and progenitor cell biology to advance the identity of cardiovascular, lung and blood diseases. The proposed ACC has the knowledgeable and experienced faculty and staff and a plan to provide outstanding administrative and technical support to the NHLBI Progenitor Cell Biology Consortium. The proposed ACC has a strong track record in and will organize meeting and conference calls, maintain written documents and a website, award subcontracts, oversee review and award of pilot and ancillary study funds, and process those studies, renewals and reports. The communications and professorial (instructional) strengths of the proposed ACC will enhance coordination of skills development activities. By bringing together collaborating groups of progenitor cell biology investigators and their data, organizing communications and information, and disseminating findings, the ACC will make an important contribution to the success of the NHLBI Progenitor Cell Biology Consortium.

Agency
National Institute of Health (NIH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL099997-06
Application #
8656741
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Buxton, Denis B
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Shiba, Yuji; Filice, Dominic; Fernandes, Sarah et al. (2014) Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model. J Cardiovasc Pharmacol Ther 19:368-381
Wu, Chao; Bardes, Eric E; Jegga, Anil G et al. (2014) ToppMiR: ranking microRNAs and their mRNA targets based on biological functions and context. Nucleic Acids Res 42:W107-13
Saez, Borja; Ferraro, Francesca; Yusuf, Rushdia Z et al. (2014) Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood 124:2937-47
Zhao, Rui; Fallon, Timothy R; Saladi, Srinivas Vinod et al. (2014) Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 30:151-65
Cosgrove, Benjamin D; Gilbert, Penney M; Porpiglia, Ermelinda et al. (2014) Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nat Med 20:255-64
Tiburcy, Malte; Meyer, Tim; Soong, Poh Loong et al. (2014) Collagen-based engineered heart muscle. Methods Mol Biol 1181:167-76
Lee, Joo-Hyeon; Bhang, Dong Ha; Beede, Alexander et al. (2014) Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell 156:440-55
Sandler, Vladislav M; Lis, Raphael; Liu, Ying et al. (2014) Reprogramming human endothelial cells to haematopoietic cells requires vascular induction. Nature 511:312-8
Tiburcy, Malte; Zimmermann, Wolfram-Hubertus (2014) Modeling myocardial growth and hypertrophy in engineered heart muscle. Trends Cardiovasc Med 24:7-13
Shkolnikov, Viktor; Santiago, Juan G (2014) Coupling isotachophoresis with affinity chromatography for rapid and selective purification with high column utilization, part 1: theory. Anal Chem 86:6220-8

Showing the most recent 10 out of 15 publications