The lymphatic system performs many crucial functions in health, gathering approximately 6 liters/day of interstitial fluid and returning it tothe venous system. As this fluid is filtered, undesirable elements such as tumor cells and foreign pathogens are normally destroyed in lymph nodes. This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease, for which there is no known cure, affects a large number of cancer patients who have undergone lymph node dissection, as well as trauma victims. The lymphatic system is also the major transport route for metastases of the most deadly cancers. Understanding and modeling the transport of lymph remains a challenge. Much of the pumping work comes from the contraction of lymphatic vessel smooth muscle, with valves preventing backflow. We are developing a multi-scale network model of the lymphatic circulation based on a combination of physical laws, material descriptions, and models of active cellular processes. Goals of this iterative model development process are to gain a better understanding of normal lymphatic function as well as multiple diseases.
The lymphatic system is directly involved in Lymphedema, an incurable condition that affects a large percentage of cancer patients who have undergone surgery. It is also involved in the spread of cancer, serving as the principal route of distributio for cancer metastases.
|Margaris, Konstantinos N; Nepiyushchikh, Zhanna; Zawieja, David C et al. (2016) Microparticle image velocimetry approach to flow measurements in isolated contracting lymphatic vessels. J Biomed Opt 21:25002|
|Jamalian, Samira; Davis, Michael J; Zawieja, David C et al. (2016) Network Scale Modeling of Lymph Transport and Its Effective Pumping Parameters. PLoS One 11:e0148384|
|Bertram, Christopher D; Macaskill, Charlie; Davis, Michael J et al. (2016) Consequences of intravascular lymphatic valve properties: a study of contraction timing in a multi-lymphangion model. Am J Physiol Heart Circ Physiol 310:H847-60|
|Bertram, C D; Macaskill, C; Moore Jr, J E (2016) Pump function curve shape for a model lymphatic vessel. Med Eng Phys 38:656-63|
|Jafarnejad, M; Cromer, W E; Kaunas, R R et al. (2015) Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells. Am J Physiol Heart Circ Physiol 308:H697-706|
|Kornuta, Jeffrey A; Nepiyushchikh, Zhanna; Gasheva, Olga Y et al. (2015) Effects of dynamic shear and transmural pressure on wall shear stress sensitivity in collecting lymphatic vessels. Am J Physiol Regul Integr Comp Physiol 309:R1122-34|
|Zolla, Valerio; Nizamutdinova, Irina Tsoy; Scharf, Brian et al. (2015) Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging Cell 14:582-94|
|Jafarnejad, Mohammad; Woodruff, Matthew C; Zawieja, David C et al. (2015) Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes. Lymphat Res Biol 13:234-47|
|Wilson, John T; van Loon, Raoul; Wang, Wei et al. (2015) Determining the combined effect of the lymphatic valve leaflets and sinus on resistance to forward flow. J Biomech 48:3584-90|
|Bazigou, Eleni; Wilson, John T; Moore Jr, James E (2014) Primary and secondary lymphatic valve development: molecular, functional and mechanical insights. Microvasc Res 96:38-45|
Showing the most recent 10 out of 15 publications