The lymphatic system performs many crucial functions in health, gathering approximately 6 liters/day of interstitial fluid and returning it tothe venous system. As this fluid is filtered, undesirable elements such as tumor cells and foreign pathogens are normally destroyed in lymph nodes. This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease, for which there is no known cure, affects a large number of cancer patients who have undergone lymph node dissection, as well as trauma victims. The lymphatic system is also the major transport route for metastases of the most deadly cancers. Understanding and modeling the transport of lymph remains a challenge. Much of the pumping work comes from the contraction of lymphatic vessel smooth muscle, with valves preventing backflow. We are developing a multi-scale network model of the lymphatic circulation based on a combination of physical laws, material descriptions, and models of active cellular processes. Goals of this iterative model development process are to gain a better understanding of normal lymphatic function as well as multiple diseases.

Public Health Relevance

The lymphatic system is directly involved in Lymphedema, an incurable condition that affects a large percentage of cancer patients who have undergone surgery. It is also involved in the spread of cancer, serving as the principal route of distributio for cancer metastases.

National Institute of Health (NIH)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZEB1)
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Lee, Albert
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Texas A&M University
Schools of Medicine
College Station
United States
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