From 2000-2010, the annual number of new HIV diagnoses among MSM aged 13-24 years old more than doubled. There are stark racial and ethnic disparities in the incidence of new HIV infections among YMSM; 13- 24 year old racial and ethnic minority MSM now represent a rapidly growing share of all new HIV infections. Although the likelihood of HIV acquisition is greater at older ages, many of the cognitive and behavioral risk factors that contribute to the risk of HIV infection rates develop in adolescence. As adolescent MSM (AMSM; 13-18 years old) begin to develop and express gender and sexual identities, to experiment and begin sexual behaviors, and to begin to establish a sense of self, there is the opportunity to parallel this period of growth with targeted, tailored interventions that equip AMSM with the life skills they need to reduce their vulnerability to HIV risk and to establish the life skills necessary to manage risk. We developed a mobile-friendly WebApp intervention focused on life skills training (iCON) across 16 topics, ranging from stigma and discrimination to sexual health, with links to local resources. In the proposed activities, we will adapt iCON for four U.S regions heavily impacted by HIV, and revise the content to include materials that are age-appropriate for 13 to 18 year- olds. Given the role that stigma and social isolation plays in the lives of many AMSM, we also propose to embed a peer-to-peer motivational interviewing component to iCON, allowing participants to access motivational interviewing counseling via VSee video-chat. With a large and diverse sample (n=500), we will test the efficacy of the intervention, now referred to as iCON+, on cognitive and behavioral HIV-related outcomes using a two-arm randomized control design. In addition, we examine whether structural characteristics in a region (e.g., race/ethnicity segregation, HIV prevalence) influence the efficacy of the proposed intervention. We propose the following Specific Aims: (1) Adapt a multilevel, online life skills intervention (iCON+) to address HIV vulnerability among AMSM living in four heavily impacted regions constituting diverse racial/ethnic and geographic areas (Chicago-Detroit; Atlanta-Washington, DC; Memphis- New Orleans; San Francisco-San Diego) in the US. (2) Test the efficacy of iCON+, as compared to a delayed intervention condition, to improve cognitive (e.g., comfort discussing sexuality; HIV prevention attitudes, norms, self-efficacy, behavioral intentions) and behavioral (e.g., condom use, HIV testing, PrEP use) factors using a prospective RCT design. (3) Examine the differential efficacy of iCON+ in improving psychosocial mediators (e.g., personal competency) associated with our outcomes and (4) Examine how socio-ecological determinants at the individual (e.g., race/ethnicity, urbanity) and regional (e.g., socioeconomic disadvantage, HIV prevalence) level are associated with iCON+'s efficacy.

Public Health Relevance

PROJECT RELEVANCE Consistent with the National HIV/AIDS Prevention Plan's call to reduce new HIV infections by intensifying HIV prevention efforts in communities where HIV is most heavily concentrated, we propose to deliver and test a life skills intervention targeting the key domains that fuel HIV disparities among adolescent MSM in the United States. This RCT will yield important information regarding the delivery of a developmentally-appropriate HIV prevention program that reaches racial/ethnic and socioeconomically diverse sample of AMSM across four regions in the United States.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01MD011274-01
Application #
9204446
Study Section
Special Emphasis Panel (ZMD1-DRI (M2))
Program Officer
Alvidrez, Jennifer L
Project Start
2016-07-28
Project End
2021-02-28
Budget Start
2016-07-28
Budget End
2017-02-28
Support Year
1
Fiscal Year
2016
Total Cost
$2,003,747
Indirect Cost
$308,392
Name
University of Pennsylvania
Department
Other Health Professions
Type
Schools of Nursing
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104