This application for renewal of the California NeuroAIDS Tissue Network (CNTN) responds to RFA-MH-08-021. The CNTN is part of the National NeuroAIDS Tissue Consortium (NNTC) which includes sites at the Mt. Sinai School of Medicine, UCLA, and University of Texas Galveston. Consistent with the RFA's requirements, this application is in two parts: Part A (identical for all 4 applications) describes the overall aims and operations of the NNTC, including common protocols and shared scientific agendas. Part B is the Site specific application, which is described below. The CNTN's main objective has been to perform careful neuromedical, neuropsychiatric, and laboratory evaluations of persons with HIV so that these data can be linked to neuropathological information obtained from brain and other tissues of participants who die on study and consent to organ donation. This enables us to support research throughout the country by providing investigators with tissues, fluids, and data that will keep them to answer critical questions on the causes and possible treatment and prevention of neurologic disease in AIDS. To date CNTN has antemortem clinical information on 544 persons living with HIV and have analyzed brain and other tissues from 198 HIV+ persons. We have also banked tissues from 20 HIV uninfected persons for comparison study. As an active member of the NNTC, CNTN contributes data to the NNTC Coordinating Office, which has enabled NNTC to respond to 212 requests from various investigators. In this continuation phase CNTN plans to augment its resource mission with a scientific agenda, as envisioned in the RFA. Initial scientific analyses will focus on neuropathologic characteristics of immune reconstitution inflammatory syndrome, an exploration of the cellular basis and structural correlates of HIV leukoencephalopathy, mechanisms of early neuronal aging among persons with prolonged exposure to HIV and ARV treatment, and the role of viral drug resistance in HIV brain disease. Our resource contributions to the NNTC will include membership in the NNTC's Scientific Leadership Group, collaboration on NNTC-wide preliminary studies and QA activities, technical assistance in areas of CNTN's expertise, and continuing contribution of data from antemortem and postmortem evaluations. Part A:

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-H (02))
Program Officer
Colosi, Deborah
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Dever, Seth M; Costin, Blair N; Xu, Ruqiang et al. (2014) Differential expression of the alternatively spliced OPRM1 isoform ?-opioid receptor-1K in HIV-infected individuals. AIDS 28:19-30
Zenón, Frances; Segarra, Annabell C; Gonzalez, Mariangeline et al. (2014) Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. J Neuroimmune Pharmacol 9:703-15
Harezlak, J; Cohen, R; Gongvatana, A et al. (2014) Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART. J Neurovirol 20:294-303
Vartak-Sharma, Neha; Gelman, Benjamin B; Joshi, Chaitanya et al. (2014) Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-?B signaling and excitatory amino acid transporter-2 repression. J Biol Chem 289:19599-612
Cassol, Edana; Misra, Vikas; Dutta, Anupriya et al. (2014) Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment. AIDS 28:1579-91
Grant, Igor; Franklin Jr, Donald R; Deutsch, Reena et al. (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055-62
Meulendyke, Kelly A; Ubaida-Mohien, Ceereena; Drewes, Julia L et al. (2014) Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease. J Infect Dis 210:904-12
Marquine, María J; Umlauf, Anya; Rooney, Alexandra S et al. (2014) The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment. J Acquir Immune Defic Syndr 65:190-7
Gill, Alexander J; Kovacsics, Colleen E; Cross, Stephanie A et al. (2014) Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders. J Clin Invest 124:4459-72
Lucas, Calixto-Hope; Calvez, Mathilde; Babu, Roshni et al. (2014) Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Neurosci Lett 558:97-102

Showing the most recent 10 out of 38 publications