The Administrative Core will continue to function as the chief administrative unit of the Columbia University Superfund Research Program (SRP). In this capacity, the Administrative Core is responsible for the supervision, coordination, guidance and financial accountability of the entire SRP. The goals of the Core are: a) to provide leadership to facilitate interactions and communication among Investigators both at formal (e.g., meetings and seminars) and informal levels;2) to foster interactions among Research Projects, Research Support Cores, the Research Translation Core, and the Community Engagement Core, and to facilitate the dissemination of information across these units and to the outside world, both domestically and abroad;3) to supervise the utilization of the Research Support Core Facilities; 4) to coordinate the reviews of SRP activities by organizing an annual 1.5 visit by our External Advisory Committee;5) to coordinate SRP activities, including seminars, retreats, symposia, and the preparation of the annual progress report;6) to ensure dissemination of findings and attendance at the annual overall SRP meeting;and 7) to manage the program's budget. The Administrative Core will confine to handle all financial aspects of the SRP and the component projects. The Core and the Columbia University SRP at large have been fortunate to be strongly supported by Institutional Support from the Mailman School of Public Health (MSPH) and from the Lamont-Doherty Earth Observatory (LDEO), a component of the Earth Institute at Columbia. These institutions have provided full salary support for an Administrative Coordinator at MSPH and LDEO, and full salary support for a Bangladesh Project Director at Columbia. This support will continue throughout the proposed grant cycle. As in the past, the Director and Associate Director will work with investigators to develop new projects. In the past, some of this pilot work has translated into independent R01 grant support for ancillary projects that contribute to the overall mission of the NIEHS SRP program;these have enabled our Program to be exponentially greater than the sum of its parts.
A major research center like the Superfund Research Program requires strong leadership, management, organizational skills and fiscal management to achieve its scientific and community related goals. The experienced leadership in this Administrative Core has experience in leading a complex yet highly productive program that has garnered extraordinary support from its government and community partners. The Core is poised to continue this leadership in the next grant cycle. RELEVANCE (See instructions): A major research center like the Superfund Research Program requires strong leadership, management, organizational skills and fiscal management to achieve its scientific and community related goals. The experienced leadership in this Administrative Core has experience in leading a complex yet highly productive program that has garnered extraordinary support from its government and community partners. The Core is poised to continue this leadership in the next grant cycle.
|Wood, Michael R; Noetzel, Meredith J; Poslusney, Michael S et al. (2016) Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs. Bioorg Med Chem Lett :|
|Dean, Brian; Hopper, Shaun; Conn, P Jeffrey et al. (2016) Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations. Neuropsychopharmacology 41:1620-8|
|Gould, Robert W; Nedelcovych, Michael T; Gong, Xuewen et al. (2016) State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects. Neuropharmacology 102:244-53|
|Ghoshal, A; Rook, J M; Dickerson, J W et al. (2016) Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology 41:598-610|
|Panarese, Joseph D; Cho, Hykeyung P; Adams, Jeffrey J et al. (2016) Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorg Med Chem Lett 26:3822-5|
|Kurata, Haruto; Gentry, Patrick R; Kokubo, Masaya et al. (2015) Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges. Bioorg Med Chem Lett 25:690-4|
|Pancani, Tristano; Foster, Daniel J; Moehle, Mark S et al. (2015) Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice. Proc Natl Acad Sci U S A 112:14078-83|
|Gould, R W; Dencker, D; Grannan, M et al. (2015) Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice. ACS Chem Neurosci 6:1683-95|
|Maltese, Marta; Martella, Giuseppina; Madeo, Graziella et al. (2014) Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors. Mov Disord 29:1655-65|
|Jones, Carrie K; Sheffler, Douglas J; Williams, Richard et al. (2014) Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. Bioorg Med Chem Lett 24:1067-70|
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