The Administrative Core will continue to function as the chief administrative unit of the Columbia University Superfund Research Program (SRP). In this capacity, the Administrative Core is responsible for the supervision, coordination, guidance and financial accountability of the entire SRP. The goals of the Core are: a) to provide leadership to facilitate interactions and communication among Investigators both at formal (e.g., meetings and seminars) and informal levels;2) to foster interactions among Research Projects, Research Support Cores, the Research Translation Core, and the Community Engagement Core, and to facilitate the dissemination of information across these units and to the outside world, both domestically and abroad;3) to supervise the utilization of the Research Support Core Facilities; 4) to coordinate the reviews of SRP activities by organizing an annual 1.5 visit by our External Advisory Committee;5) to coordinate SRP activities, including seminars, retreats, symposia, and the preparation of the annual progress report;6) to ensure dissemination of findings and attendance at the annual overall SRP meeting;and 7) to manage the program's budget. The Administrative Core will confine to handle all financial aspects of the SRP and the component projects. The Core and the Columbia University SRP at large have been fortunate to be strongly supported by Institutional Support from the Mailman School of Public Health (MSPH) and from the Lamont-Doherty Earth Observatory (LDEO), a component of the Earth Institute at Columbia. These institutions have provided full salary support for an Administrative Coordinator at MSPH and LDEO, and full salary support for a Bangladesh Project Director at Columbia. This support will continue throughout the proposed grant cycle. As in the past, the Director and Associate Director will work with investigators to develop new projects. In the past, some of this pilot work has translated into independent R01 grant support for ancillary projects that contribute to the overall mission of the NIEHS SRP program;these have enabled our Program to be exponentially greater than the sum of its parts.

Public Health Relevance

A major research center like the Superfund Research Program requires strong leadership, management, organizational skills and fiscal management to achieve its scientific and community related goals. The experienced leadership in this Administrative Core has experience in leading a complex yet highly productive program that has garnered extraordinary support from its government and community partners. The Core is poised to continue this leadership in the next grant cycle. RELEVANCE (See instructions): A major research center like the Superfund Research Program requires strong leadership, management, organizational skills and fiscal management to achieve its scientific and community related goals. The experienced leadership in this Administrative Core has experience in leading a complex yet highly productive program that has garnered extraordinary support from its government and community partners. The Core is poised to continue this leadership in the next grant cycle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH087965-03
Application #
8377750
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2012-01-01
Budget End
2012-12-31
Support Year
3
Fiscal Year
2012
Total Cost
$209,366
Indirect Cost
$75,157
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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Long, Madeline F; Engers, Julie L; Chang, Sichen et al. (2017) Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorg Med Chem Lett 27:4999-5001
Bender, Aaron M; Weiner, Rebecca L; Luscombe, Vincent B et al. (2017) Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Bioorg Med Chem Lett 27:3576-3581
Bender, Aaron M; Weiner, Rebecca L; Luscombe, Vincent B et al. (2017) Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype. Bioorg Med Chem Lett 27:2479-2483
Wood, Michael R; Noetzel, Meredith J; Melancon, Bruce J et al. (2017) Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia. ACS Med Chem Lett 8:233-238
Lindsley, Craig W; Emmitte, Kyle A; Hopkins, Corey R et al. (2016) Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chem Rev 116:6707-41

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