Despite its remarkable success, one of the significant limitations of Deep Brain Stimulation (DBS) is its incompatibility with magnetic resonance imaging (MRI). In this application we propose to design, develop and test novel MRI conditional leads based on resistive tapered stripline technology. The innovative high-resistance technology will allow for decreased Specific Absorption Rate and reducing artifacts of the MRI data while maintaining low lead resistivity for continuous current injection. Electromagnetic numerical simulation will be used to support the design and will be tested thoroughly on healthy animals for biocompatibility and validation. The long-term goal of this project is the development of the DBS systems compatible with MRI and other external radiofrequency sources, with significant benefits to patients that may require neural implantations in pathological conditions such as Parkinson's disease, epilepsy, and stroke.
The proposed research aims at designing, developing and testing novel polymer-based Resistive Tapered Stripline (RTS) technology for Deep Brain Stimulation and Magnetic Resonance Imaging. The development of such novel technology could result in significant benefits to patients that suffer from some medically refractory pathological conditions such as Parkinson's disease, epilepsy, and stroke.
|Poulsen, Catherine; Wakeman, Daniel G; Atefi, Seyed Reza et al. (2017) Polymer thick film technology for improved simultaneous dEEG/MRI recording: Safety and MRI data quality. Magn Reson Med 77:895-903|
|Ahmadi, Emad; Katnani, Husam A; Daftari Besheli, Laleh et al. (2016) An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging. Radiology 280:595-601|
|Lee, Karen E; Bhati, Mahendra T; Halpern, Casey H (2016) A Commentary on Attitudes Towards Deep Brain Stimulation for Addiction. J Neurol Neuromedicine 1:1-3|
|Serano, Peter; Angelone, Leonardo M; Katnani, Husam et al. (2015) A novel brain stimulation technology provides compatibility with MRI. Sci Rep 5:9805|