Despite its remarkable success, one of the significant limitations of Deep Brain Stimulation (DBS) is its incompatibility with magnetic resonance imaging (MRI). In this application we propose to design, develop and test novel MRI conditional leads based on resistive tapered stripline technology. The innovative high-resistance technology will allow for decreased Specific Absorption Rate and reducing artifacts of the MRI data while maintaining low lead resistivity for continuous current injection. Electromagnetic numerical simulation will be used to support the design and will be tested thoroughly on healthy animals for biocompatibility and validation. The long-term goal of this project is the development of the DBS systems compatible with MRI and other external radiofrequency sources, with significant benefits to patients that may require neural implantations in pathological conditions such as Parkinson's disease, epilepsy, and stroke.

Public Health Relevance

The proposed research aims at designing, developing and testing novel polymer-based Resistive Tapered Stripline (RTS) technology for Deep Brain Stimulation and Magnetic Resonance Imaging. The development of such novel technology could result in significant benefits to patients that suffer from some medically refractory pathological conditions such as Parkinson's disease, epilepsy, and stroke.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01NS075026-02
Application #
8605940
Study Section
Special Emphasis Panel (ZRG1-ETTN-B (52))
Program Officer
Ludwig, Kip A
Project Start
2013-02-01
Project End
2017-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
2
Fiscal Year
2014
Total Cost
$656,249
Indirect Cost
$257,762
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199