Adverse short- and medium-term respiratory effects of work at the World Trade Center (WTC) disaster site have been widely documented in Fire Department of the City of New York (FDNY) first responders and others. Our FDNY team first reported WTC cough syndrome, demonstrated that work-related exposures to the disaster site increased the odds of aerodigestive symptoms up to four years post-9/11, and showed that the prevalence of respiratory diagnoses, both self-reported and FDNY-physician diagnosed, remained elevated seven to nine years after working at the site. It remains unclear, however, whether these health effects occurred shortly after working at the disaster site or if new disease or respiratory symptoms occurred continually over subsequent years. Stated differently, it is possible that the exposure/response gradient we and others have observed for the cumulative incidence of disease and prevalent symptoms can be attributed entirely to higher incidence rates shortly after 9/11/2001, and beyond that time, there is no exposure response gradient for incident effects. We propose innovative statistical methods - parametric survival models with change points - to study the incidence of new onset obstructive airway disease (OAD) disease diagnoses and symptoms over the first ten years following WTC exposure, with the goal of determining the length of time that exposure response gradients are observed among exposed FDNY firefighters. This work will allow estimation of the length of time that a relatively short-term, high intensity exposure may be associated with incident respiratory illness.

Public Health Relevance

If WTC exposure is found to continue to be associated with elevated risk of OAD years after exposure, such a result would support current policy to provide health care for these conditions to exposed rescue/recovery workers regardless of the year of diagnosis. On the other hand, if the exposure response gradient is sufficiently attenuated by the end of this ten year follow up period, it may reassure exposed workers that their period of high risk has passed. Finally, the innovative methods proposed allow, for the first time, the quantitative estimation of persistence and/or attenuation in exposure response relationships over time, and will be applicable to many additional cohort studies of the long-term effects of short-term occupational or environmental exposures.

National Institute of Health (NIH)
National Institute for Occupational Safety and Health (NIOSH)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZOH1-GGB (55))
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Kubale, Travis
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Albert Einstein College of Medicine
United States
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Liu, Xiaoxue; Yip, Jennifer; Zeig-Owens, Rachel et al. (2017) The Effect of World Trade Center Exposure on the Timing of Diagnoses of Obstructive Airway Disease, Chronic Rhinosinusitis, and Gastroesophageal Reflux Disease. Front Public Health 5:2
Sundermann, Erin Elizabeth; Wang, Cuiling; Katz, Mindy et al. (2016) Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ?4 on memory decline in older adults. Neurobiol Aging 41:200.e7-200.e12
Hall, Charles B; Liu, Xiaoxue; Zeig-Owens, Rachel et al. (2015) The Duration of an Exposure Response Gradient between Incident Obstructive Airways Disease and Work at the World Trade Center Site: 2001-2011. PLoS Curr 7:
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