The overarching goal of this ICBG is to improve human health and well being through an integrated set of programs dedicated to the description, assessment, rational utilization, and conservation of biodiversity in Papua New Guinea (PNG). PNG is home to approximately 5% of the world's biodiversity. An understanding of the range of biological resources existing in PNG is essential for their management, for the preservation of species critical to indigenous cultures, and for the development of strategies for sustainable use. Our central hypothesis is that effective new therapeutics can be derived from the natural products of PNG's biological wealth. Such therapeutics can provide needed revenue to local stake-holders and responsible PNG institutions, and an incentive for the preservation of biological diversity. The university-based drug discovery component will focus on human immunodeficiency virus and Mycobacterium tuberculosis, while the industry based drug discovery component will focus on parasitic diseases, animal health and other therapeutic targets. The source organisms for drug discovery will be marine and terrestrial microbes and marine invertebrate animals. Documentation and preservation of traditional knowledge concerning medicinal plant use in PNG will be a second emphasis of this work. Medicinal plant surveys will be complemented by projects in support of the Traditional Medicines Taskforce, and student theses, to provide pharmacologic validation and chemical standardization of medicinal plants, and the identification of novel bioactive molecules. This research will provide professional development, educational opportunities and technology transfer for collaborating scientists and students. Conservation and biodiversity studies will center in the CTFS/SIGEO forest dynamics plot that has been established in Wanang, PNG, as part of the previous grant cycle's achievements. This plot is a unique and powerful research tool for studying forest dynamics, carbon sequestration and climate effects. Plot activities will integrate the botanical survey with the ecosystem study to include soil microbes and small plants. Outreach activities conducted as part of the Traditional Medicines and botanical survey work will foster the conservation and sustainable use of resources and provide benefits to stake-holders. Legislative initiatives developed with government input promote scientific exchange, conservation and sustainable resource use.

Public Health Relevance

This research will discover new natural products from marine and terrestrial organisms from Papua New Guinea with activity against HIV, TB and parasitic diseases. Documentation of the medicinal and economic value of indigenous organisms will provide incentive for conservation of ecosystems in PNG and new healthcare options to domestic and foreign sufferers of these infectious diseases.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01TW006671-10S1
Application #
8850600
Study Section
Program Officer
Katz, Flora N
Project Start
2014-07-01
Project End
2015-05-31
Budget Start
2014-07-01
Budget End
2015-05-31
Support Year
10
Fiscal Year
2014
Total Cost
$400,000
Indirect Cost
$116,595
Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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Larson, Erica C; Hathaway, Laura B; Lamb, John G et al. (2014) Interactions of Papua New Guinea medicinal plant extracts with antiretroviral therapy. J Ethnopharmacol 155:1433-40
Lu, Zhenyu; Koch, Michael; Harper, Mary Kay et al. (2013) Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp. J Nat Prod 76:2150-2
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