The Philippine Mollusk Symbiont ICBG (PMS ICBG) project links a biodiversity survey of marine mollusks in one of the world's hotspots of diversity, with drug discovery and enzyme bioprospecting aimed at bacterial symbionts of mollusks. Mollusks constitute the most diverse marine eukaryotic group, occupying virtually every possible ecological niche. The diversity of microbes associated with mollusks is equally vast. Within the mollusks, three particular groups exhibit what we believe to be the highest biotechnological and scientific potential: the bivalve family Teredinidae (genus Teredo) and the gastropod superfamilies Conoidea (genus Conus) and Muricoidea (genus Murex). The project directly addresses the goals of the ICBG program and will yield drug leads in central nervous system, cancer and antimicrobial areas, as well as strains and enzymes for cellulosic biofuels production. The project will characterize symbiotic diversity and pharmaceutical and biofuels potential of mollusk-associated bacteria in a comparative framework for the first time. The plan focuses on training, conservation, and the development of drug discovery and biofuels programs within the Philippines. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal and energy needs, consequent urgent conservation goals, and government and private sector commitment to education and technology to harness national human and natural resources for a sustainable future The project is led by Margo Haygood, marine microbiologist, Oregon Heath &Science University, in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Baldomero Olivera, biochemist, and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, evolutionary biologist, Academy of Natural Sciences, Philadelphia, and Daniel Distel, marine microbiologist, Ocean Genome Legacy.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01TW008163-05S1
Application #
8693423
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (52))
Program Officer
Katz, Flora N
Project Start
2008-08-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
5
Fiscal Year
2013
Total Cost
$280,000
Indirect Cost
$66,549
Name
Oregon Health and Science University
Department
Engineering (All Types)
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Teichert, Russell W; Schmidt, Eric W; Olivera, Baldomero M (2015) Constellation pharmacology: a new paradigm for drug discovery. Annu Rev Pharmacol Toxicol 55:573-89
Barghi, Neda; Concepcion, Gisela P; Olivera, Baldomero M et al. (2015) Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes. Genome Biol Evol 7:1797-814
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Puillandre, N; Bouchet, P; Duda Jr, T F et al. (2014) Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea). Mol Phylogenet Evol 78:290-303
Lin, Zhenjian; Koch, Michael; Pond, Christopher D et al. (2014) Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. J Antibiot (Tokyo) 67:121-6
Imperial, Julita S; Cabang, April B; Song, Jie et al. (2014) A family of excitatory peptide toxins from venomous crassispirine snails: using Constellation Pharmacology to assess bioactivity. Toxicon 89:45-54

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