COGA (Collaborative Study On the Genetics of Alcoholism) focuses on the identification and characterization of gene variants that contribute to the etiology of alcohol abuse, alcoholism and comorbid disorders, a goal more readily attained if clinical data and biological materials derived from a large number of subjects are ultimately shared by many researchers. This proposal summarizes the current activities of the Nl/'OWCOGA Sharing Repository (NCSR) and describes ongoing plans to expand its scope of activities to better serve the goals of the NIAAA and COGA. The COGA biosamples are housed in the Rutgers University Cell and DNA Repository (RUCDR), under the direction of Dr. Jay Tischfleld. For neariy twenty years, the NCSR has produced lymphoblast cell lines (LCLs), DNA from blood and LCLs, and (in the last two years) RNA from LCLs. The biosamples are available to COGA investigators and, along with the associated clinical data, to NIAAA-approved researchers outside of COGA. Genotyping of DNA provided by the NCSR produces data that will continue to Identify gene variants influencing endophenotypes and clinical phenotypes related to alcohol dependence and corresponding vulnerabilities, while the LCLs and blood-derived DNA provide a unique platform for functional genomic and epigenomic studies, respectively. The data management component of NCSR maintains an """"""""anonymized"""""""" database on family structure, age, sex, clinical status, and diagnoses (described in Data Management, Section V). COGA Pis and NIAAA-approved researchers may access data related to NCSR biosamples through a secure web site (www.niaaaqenetics.orq/).

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10AA008401-24
Application #
8381793
Study Section
Special Emphasis Panel (ZAA1-CC)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
24
Fiscal Year
2012
Total Cost
$433,546
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
DUNS #
040796328
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
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Chorlian, David B; Rangaswamy, Madhavi; Manz, Niklas et al. (2017) Genetic correlates of the development of theta event related oscillations in adolescents and young adults. Int J Psychophysiol 115:24-39
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Grant, Julia D; Agrawal, Arpana; Werner, Kimberly B et al. (2017) Phenotypic and familial associations between childhood maltreatment and cannabis initiation and problems in young adult European-American and African-American women. Drug Alcohol Depend 179:146-152
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Mathies, Laura D; Aliev, Fazil; COGA Investigators et al. (2017) Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. Alcohol Clin Exp Res 41:2033-2040
Bucholz, Kathleen K; McCutcheon, Vivia V; Agrawal, Arpana et al. (2017) Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. Alcohol Clin Exp Res 41:359-368
Wang, Jian; Talluri, Rajesh; Shete, Sanjay (2017) Selection of X-chromosome Inactivation Model. Cancer Inform 16:1176935117747272
Agrawal, Arpana; Tillman, Rebecca; Grucza, Richard A et al. (2017) Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. J Affect Disord 213:96-104

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