1. An Overview of Subject Selection and Characteristics The original COGA Guidelines for selection of probands, Identiflcation of appropriate relatives, and selection of controls and their families are outiined above. The proposed work will recruit no new families and will only draw upon members of the existing pedigrees. Appropriate members of COGA probands and comparison families will be invited to continue to participate In the prospective panel study, along with children who "age up" to the 12-year minimum age required for participation. Alcoholic probands had been originally ascertained from consecutive admissions to public and private inpatient and outpatient treatment facilities at each ofthe COGA participating sites. This Included individuals who fulfilled the COGA criteria for alcohol dependence, and who had multiple alcohol-dependent relatives living within 50 to 150 miles ofthe COGA Centers. Comparison families were selected using different methods across the subject collection sites, with approaches including random mailings to individuals affiliated with the respective university, people who are attending dental and medical clinic patients, and a random assessment through public records. Potential probands were excluded from the study if they had a mortal illness, were current IV drug users, reported an extensive history of IV drug use (31+ times), or were known to be infected with the HIV virus. These exclusion criteria are not applied to family members. In general, for all subjects medical or psychiatric conditions were the only general grounds for exclusion if it seemed probable that they might compromise a subject's ability to provide informed consent (e.g., advanced Alzheimer's disease) or hinder one's participation in the blood sampling or electrophysiological portions ofthe study (e.g., liver disease, neurological disease, head injuries, etc.). For the current ongoing study of adolescents and young adults, individuals younger than the age of majority (18 years) are assessed (including direct interviews, neurophysiological and electrophysiological testing, and blood samples) only following written consent is obtained from the parents and assent of the subject. The study of adolescents and young adults is essential to facilitate genetic analyses of characteristics related to the onset of alcohol and substance use and associated problems. These findings will facilitate our understanding of the potential importance of specific genetic markers and enhance our understanding of eariy drinking parameters.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10AA008401-25
Application #
8537094
Study Section
Special Emphasis Panel (ZAA1-CC)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
25
Fiscal Year
2013
Total Cost
$491,127
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
DUNS #
040796328
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Chartier, Karen G; Dick, Danielle M; Almasy, Laura et al. (2016) Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. J Stud Alcohol Drugs 77:393-404
Olfson, E; Saccone, N L; Johnson, E O et al. (2016) Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Mol Psychiatry 21:601-7
Oni, Eileen N; Hart, Ronald P (2016) Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. Curr Pharmacol Rep 2:203-210
Sherva, Richard; Wang, Qian; Kranzler, Henry et al. (2016) Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry 73:472-80
Johnson, Eric O; Hancock, Dana B; Levy, Joshua L et al. (2016) KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. Addict Biol 21:1217-1232
Dick, Danielle M; Adkins, Amy E; Kuo, Sally I-Chun (2016) Genetic influences on adolescent behavior. Neurosci Biobehav Rev 70:198-205
Zhao, Jiwei; Zhang, Heping (2016) Modeling Multiple Responses via Bootstrapping Margins with an Application to Genetic Association Testing. Stat Interface 9:47-56
Melroy-Greif, Whitney E; Simonson, Matthew A; Corley, Robin P et al. (2016) Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. Nicotine Tob Res :
Agrawal, Arpana; Edenberg, Howard J; Gelernter, Joel (2016) Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. J Stud Alcohol Drugs 77:676-80

Showing the most recent 10 out of 419 publications