1. An Overview of Subject Selection and Characteristics The original COGA Guidelines for selection of probands, Identiflcation of appropriate relatives, and selection of controls and their families are outiined above. The proposed work will recruit no new families and will only draw upon members of the existing pedigrees. Appropriate members of COGA probands and comparison families will be invited to continue to participate In the prospective panel study, along with children who "age up" to the 12-year minimum age required for participation. Alcoholic probands had been originally ascertained from consecutive admissions to public and private inpatient and outpatient treatment facilities at each ofthe COGA participating sites. This Included individuals who fulfilled the COGA criteria for alcohol dependence, and who had multiple alcohol-dependent relatives living within 50 to 150 miles ofthe COGA Centers. Comparison families were selected using different methods across the subject collection sites, with approaches including random mailings to individuals affiliated with the respective university, people who are attending dental and medical clinic patients, and a random assessment through public records. Potential probands were excluded from the study if they had a mortal illness, were current IV drug users, reported an extensive history of IV drug use (31+ times), or were known to be infected with the HIV virus. These exclusion criteria are not applied to family members. In general, for all subjects medical or psychiatric conditions were the only general grounds for exclusion if it seemed probable that they might compromise a subject's ability to provide informed consent (e.g., advanced Alzheimer's disease) or hinder one's participation in the blood sampling or electrophysiological portions ofthe study (e.g., liver disease, neurological disease, head injuries, etc.). For the current ongoing study of adolescents and young adults, individuals younger than the age of majority (18 years) are assessed (including direct interviews, neurophysiological and electrophysiological testing, and blood samples) only following written consent is obtained from the parents and assent of the subject. The study of adolescents and young adults is essential to facilitate genetic analyses of characteristics related to the onset of alcohol and substance use and associated problems. These findings will facilitate our understanding of the potential importance of specific genetic markers and enhance our understanding of eariy drinking parameters.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZAA1-CC)
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Suny Downstate Medical Center
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Wetherill, Leah; Agrawal, Arpana; Kapoor, Manav et al. (2015) Association of substance dependence phenotypes in the COGA sample. Addict Biol 20:617-27
Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B et al. (2015) The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. Int J Psychophysiol 97:310-22
Palmer, Rohan H C; Brick, Leslie; Nugent, Nicole R et al. (2015) Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. Addiction 110:530-7
Blednov, Yuri A; Benavidez, Jillian M; Black, Mendy et al. (2015) Peroxisome proliferator-activated receptors ? and ? are linked with alcohol consumption in mice and withdrawal and dependence in humans. Alcohol Clin Exp Res 39:136-45
Hartz, Sarah M; Bierut, Laura J; Pato, Michele T (2014) In reply. JAMA Psychiatry 71:969
Taylor, Amanda; Wang, Ke-Sheng (2014) Association between DPYSL2 gene polymorphisms and alcohol dependence in Caucasian samples. J Neural Transm (Vienna) 121:105-11
Hartz, Sarah M; Pato, Carlos N; Medeiros, Helena et al. (2014) Comorbidity of severe psychotic disorders with measures of substance use. JAMA Psychiatry 71:248-54
Jiang, Yuan; Li, Ni; Zhang, Heping (2014) Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau. J Am Stat Assoc 109:905-930
Li, Dawei; Sulovari, Arvis; Cheng, Chao et al. (2014) Association of gamma-aminobutyric acid A receptor *2 gene (GABRA2) with alcohol use disorder. Neuropsychopharmacology 39:907-18
Wang, Shaolin; D van der Vaart, Andrew; Xu, Qing et al. (2014) Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. Hum Genet 133:575-86

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