The primary objective of the Radiological Physics Center (RPC) is to assure NCI and the cooperative clinical trial groups that participating institutions have adequate quality assurance (QA) procedures and no major systematic dosimetry discrepancies, so they can be expected to deliver radiation treatments that are clinically comparable to other institutions in the cooperative group. In order to accomplish this objective, the RPC monitors the basic treatment unit output and brachytherapy source strength, the dosimetry data used by the institution, the calculation algorithms used in treatment planning, and QA procedures. The methods of monitoring include on-site dosimetry review visits and various remote audit tools. During on-site reviews, key personnel are interviewed, physical measurements are made on therapy machines, dosimetry and QA data are reviewed, treatment planning algorithms are tested and patient dose calculations are evaluated. The remote audit tools include: 1) mailed TLD evaluated on a periodic basis to verify output calibration;2) comparison of dosimetry data with RPC "standard" data to verify comparability of the dosimetry data;3) evaluation of reference and/or actual patient calculations to verify the treatment planning algorithms;4) review of an institution's written QA procedures and records;and 5) mailed anthropomorphic phantoms to verify tumor dose delivery for special treatment techniques. The RPC continuously modifies its techniques to reflect new protocols and changes in practice at participating institutions. The RPC currently monitors 1338 radiation therapy facilities. Any discrepancies found by the RPC are pursued to help the institution resolve them. Thus, the RPC's overall QA program impacts not only on clinical trial patients, but on the quality of all patients treated at the institution.

Public Health Relevance

The RPC serves as a resource in radiation dosimetry and physics to the radiotherapy community and to the cooperative groups and collaborates with the 4 radiotherapy QA offices. The RPC provides advice to the cooperative groups on QA questions, and on the development of the radiotherapy section of protocols. The RPC continues to research dosimetry questions related to the use of a wide variety of therapy equipment to deliver clinically comparable treatments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA010953-44
Application #
8245007
Study Section
Subcommittee G - Education (NCI)
Program Officer
Deye, James
Project Start
1978-09-01
Project End
2013-12-31
Budget Start
2012-01-12
Budget End
2012-12-31
Support Year
44
Fiscal Year
2012
Total Cost
$2,388,541
Indirect Cost
$471,031
Name
University of Texas MD Anderson Cancer Center
Department
Radiation-Diagnostic/Oncology
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Pulliam, Kiley B; Followill, David; Court, Laurence et al. (2014) A six-year review of more than 13,000 patient-specific IMRT QA results from 13 different treatment sites. J Appl Clin Med Phys 15:4935
Melidis, Christos; Bosch, Walter R; Izewska, Joanna et al. (2014) Radiation therapy quality assurance in clinical trials--Global Harmonisation Group. Radiother Oncol 111:327-9
McKenzie, Elizabeth M; Balter, Peter A; Stingo, Francesco C et al. (2014) Reproducibility in patient-specific IMRT QA. J Appl Clin Med Phys 15:4741
Kry, Stephen F; Molineu, Andrea; Kerns, James R et al. (2014) Institutional patient-specific IMRT QA does not predict unacceptable plan delivery. Int J Radiat Oncol Biol Phys 90:1195-201
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Gibbons, John P; Antolak, John A; Followill, David S et al. (2014) Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71. Med Phys 41:031501
Ryu, Samuel; Pugh, Stephanie L; Gerszten, Peter C et al. (2014) RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: phase 2 results. Pract Radiat Oncol 4:76-81
Weber, Damien C; Vallet, Veronique; Molineu, Andrea et al. (2014) IMRT credentialing for prospective trials using institutional virtual phantoms: results of a joint European Organization for the Research and Treatment of Cancer and Radiological Physics Center project. Radiat Oncol 9:123
Moyers, M F; Ibbott, G S; Grant, R L et al. (2014) Independent dose per monitor unit review of eight U.S.A. proton treatment facilities. Med Phys 41:012103

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