This application is a request for continued support (in part) for the EORTC Data Center. The purpose of the grant is to assist the EORTC Data Center in providing statistical assistance and expertise to the clinical cooperative groups of the EORTC. This includes advice on the design of multicenter clinical trials, writing of protocols, design of forms, development of data handling and processing, quality assurance both at the Data Center and in situ, central randomization, and use of advanced statistical and computer techniques. Trial data are made available to NCI whenever requested (196 multicenter trials in progress). The EORTC Data Center has its own research program in applied statistics and methodology of clinical trials. To facilitate communication, the EORTC Data Center has developed a private electronic network (EuroCODE) which permits on-line randomization, electronic mail, access to a number of dedicated databases, and the use of PDQ.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Cancer Clinical Investigation Review Committee (CCI)
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European Org/Research/Treatment/Cancer
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Baumert, Brigitta G; Hegi, Monika E; van den Bent, Martin J et al. (2016) Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol 17:1521-1532
Fei, F; Messina, C; Slaets, L et al. (2015) Tumour size is the only predictive factor of distant recurrence after pathological complete response to neoadjuvant chemotherapy in patients with large operable or locally advanced breast cancers: a sub-study of EORTC 10994/BIG 1-00 phase III trial. Eur J Cancer 51:301-9
Bonnefoi, H; Jacot, W; Saghatchian, M et al. (2015) Neoadjuvant treatment with docetaxel plus lapatinib, trastuzumab, or both followed by an anthracycline-based chemotherapy in HER2-positive breast cancer: results of the randomised phase II EORTC 10054 study. Ann Oncol 26:325-32
Ediebah, Divine E; Galindo-Garre, Francisca; Uitdehaag, Bernard M J et al. (2015) Joint modeling of longitudinal health-related quality of life data and survival. Qual Life Res 24:795-804
Oosterveld, Margriet; Suciu, Stefan; Muus, Petra et al. (2015) Specific scoring systems to predict survival of patients with high-risk myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) after intensive antileukemic treatment based on results of the EORTC-GIMEMA AML-10 and intergroup CRIANT studie Ann Hematol 94:23-34
Bottomley, Andrew; Tridello, Gloria; Coens, Corneel et al. (2014) An international phase 3 trial in head and neck cancer: quality of life and symptom results: EORTC 24954 on behalf of the EORTC Head and Neck and the EORTC Radiation Oncology Group. Cancer 120:390-8
Brausi, Maurizio; Oddens, Jorg; Sylvester, Richard et al. (2014) Side effects of Bacillus Calmette-Guerin (BCG) in the treatment of intermediate- and high-risk Ta, T1 papillary carcinoma of the bladder: results of the EORTC genito-urinary cancers group randomised phase 3 study comparing one-third dose with full dose an Eur Urol 65:69-76
Donker, Mila; van Tienhoven, Geertjan; Straver, Marieke E et al. (2014) Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol 15:1303-10
Bosset, Jean-François; Calais, Gilles; Mineur, Laurent et al. (2014) Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study. Lancet Oncol 15:184-90
Bonnefoi, H; Litière, S; Piccart, M et al. (2014) Pathological complete response after neoadjuvant chemotherapy is an independent predictive factor irrespective of simplified breast cancer intrinsic subtypes: a landmark and two-step approach analyses from the EORTC 10994/BIG 1-00 phase III trial. Ann Oncol 25:1128-36

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