This is a competitive renewal application on behalf of Case Western Reserve University's (CWRU) Program and its two primary teaching hospitals, MetroHealth Medical Center (MHMC) and University Hospitals of Cleveland Ireland Cancer Center (UH). The two institutions form ONE CONSORTIUM participation in ECOG activities. The CWRU program has been continuously funded for 34 years. This request describes all the integrated activities of our institution in ECOG and allows the continuation of the follow ing objectives and specific aims. 1) Permit the continuation of our participation in ECOG activities, with increased accrual to all disease oriented protocols including participation in surgical and radiation therapy oriented studies. The six-year main accrual total is 680. 2) Continue to provide follow up. The present follow up load consists of 563 patients. 3) Continue to maintain and develop additional scientific leadership in different disease committees. Dr. Hillard Lazarus has chaired the Bone Marrow Transplantation Committee, since the inception in ECOG. In the past six years, our researchers have authored 40 publications and 21 investigators/research staff are members of several ECOG committees/subcommittees. 4) Expand our participation in surgically oriented studies that require blood and tumor acquisition and perioperative adjuvant therapy. The PI is a surgical oncologist. 5) Develop Phase II and III studies that result from our Cancer Center Phase I Trials. 6) Extend Group activities of Phase I and II human studies. 7) Develop Phase I studies, as single institution or multi-institutional, and advance them to randomized clinical trials. 8) Participate in ancillary studies, chemo prevention, cancer control, and quality of Iife protocols. 9) Continue to monitor open and terminated adjuvant studies, chaired by CWRU investigators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA014548-36
Application #
7815487
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
Project Start
1978-06-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
36
Fiscal Year
2010
Total Cost
$420,754
Indirect Cost
Name
Case Western Reserve University
Department
Surgery
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Agarwala, Sanjiv S; Lee, Sandra J; Yip, Waiki et al. (2017) Phase III Randomized Study of 4 Weeks of High-Dose Interferon-?-2b in Stage T2bNO, T3a-bNO, T4a-bNO, and T1-4N1a-2a (microscopic) Melanoma: A Trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Gro J Clin Oncol 35:885-892
Ganzel, Chezi; Manola, Judith; Douer, Dan et al. (2016) Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008. J Clin Oncol 34:3544-3553
Kumar, Anita J; Gimotty, Phyllis A; Gelfand, Joel M et al. (2016) Delays in postremission chemotherapy for Philadelphia chromosome negative acute lymphoblastic leukemia are associated with inferior outcomes in patients who undergo allogeneic transplant: An analysis from ECOG 2993/MRC UK ALLXII. Am J Hematol 91:1107-1112
Loughran Jr, T P; Zickl, L; Olson, T L et al. (2015) Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998). Leukemia 29:886-94
Fielding, Adele K; Rowe, Jacob M; Buck, Georgina et al. (2014) UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia. Blood 123:843-50
Marks, David I; Moorman, Anthony V; Chilton, Lucy et al. (2013) The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial. Haematologica 98:945-52
Averbook, Bruce J; Lee, Sandra J; Delman, Keith A et al. (2013) Pediatric melanoma: analysis of an international registry. Cancer 119:4012-9
Diab, Adi; Zickl, Lynette; Abdel-Wahab, Omar et al. (2013) Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis. Leuk Res 37:32-6
Sive, Jonathan I; Buck, Georgina; Fielding, Adele et al. (2012) Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial. Br J Haematol 157:463-71
Smith, Mitchell R; Neuberg, Donna; Flinn, Ian W et al. (2011) Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997. Blood 118:3525-7

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