This is a competitive renewal application on behalf of Case Western Reserve University's (CWRU) Program and its two primary teaching hospitals, MetroHealth Medical Center (MHMC) and University Hospitals of Cleveland Ireland Cancer Center (UH). The two institutions form ONE CONSORTIUM participation in ECOG activities. The CWRU program has been continuously funded for 34 years. This request describes all the integrated activities of our institution in ECOG and allows the continuation of the follow ing objectives and specific aims. 1) Permit the continuation of our participation in ECOG activities, with increased accrual to all disease oriented protocols including participation in surgical and radiation therapy oriented studies. The six-year main accrual total is 680. 2) Continue to provide follow up. The present follow up load consists of 563 patients. 3) Continue to maintain and develop additional scientific leadership in different disease committees. Dr. Hillard Lazarus has chaired the Bone Marrow Transplantation Committee, since the inception in ECOG. In the past six years, our researchers have authored 40 publications and 21 investigators/research staff are members of several ECOG committees/subcommittees. 4) Expand our participation in surgically oriented studies that require blood and tumor acquisition and perioperative adjuvant therapy. The PI is a surgical oncologist. 5) Develop Phase II and III studies that result from our Cancer Center Phase I Trials. 6) Extend Group activities of Phase I and II human studies. 7) Develop Phase I studies, as single institution or multi-institutional, and advance them to randomized clinical trials. 8) Participate in ancillary studies, chemo prevention, cancer control, and quality of Iife protocols. 9) Continue to monitor open and terminated adjuvant studies, chaired by CWRU investigators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA014548-38
Application #
8282894
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
Project Start
1978-06-01
Project End
2014-02-28
Budget Start
2012-05-01
Budget End
2014-02-28
Support Year
38
Fiscal Year
2012
Total Cost
$354,850
Indirect Cost
$140,231
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kumar, Anita J; Gimotty, Phyllis A; Gelfand, Joel et al. (2016) Delays in postremission chemotherapy for Philadelphia chromosome negative acute lymphoblastic leukemia are associated with inferior outcomes in patients who undergo allogeneic transplant: An analysis from ECOG 2993/MRC UK ALLXII. Am J Hematol 91:1107-1112
Ganzel, Chezi; Manola, Judith; Douer, Dan et al. (2016) Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008. J Clin Oncol 34:3544-3553
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Smith, Mitchell R; Neuberg, Donna; Flinn, Ian W et al. (2011) Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997. Blood 118:3525-7
Chakravarthy, A Bapsi; Catalano, Paul J; Martenson, James A et al. (2011) Long-term follow-up of a Phase II trial of high-dose radiation with concurrent 5-fluorouracil and cisplatin in patients with anal cancer (ECOG E4292). Int J Radiat Oncol Biol Phys 81:e607-13
Fernandez, Hugo F; Sun, Zhuoxin; Litzow, Mark R et al. (2011) Autologous transplantation gives encouraging results for young adults with favorable-risk acute myeloid leukemia, but is not improved with gemtuzumab ozogamicin. Blood 117:5306-13

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