This application is submitted on behalf of the AECC in order to request continued funding via the U10 mechanism as a main institutional member of the Eastern Cooperative Oncology Group (ECOG). Einstein faculty members play key scientific and administrative leadership roles in ECOG, and accrue a large number of minority subjects and women. The Einstein Cancer Center is an NCI-designated Cancer Center that has been continuously funded since 1971, and is currently funded until July 2012 (P30 CA13330). During the last five year funding period ending 4/30/09, Einstein and its affiliates accrued a total of 604 patients into cancer clinical trials via the ECOG mechanism, including 229 therapeutic accruals from the main institution. Moreover, 64% of all subjects enrolled at the main institution were minority subjects. Einstein faculty members have provided scientific leadership in the breast (J. Sparano), lung (R. Perez-Soler), leukemia (R. Gallagher, A. Verma), head/neck (M. Haigentz), thoracic surgery (S. Keller), and Gl (L. Rajdev) committees. Einstein-affiliated investigators have authored or co-authored 28 manuscripts and 69 abstracts related to ECOG studies, including publications that have influenced the standard of care for operable breast cancer (E1199 - NEJM, 2008) and influenced choice of the standard adjuvant chemotherapy for the ongoing adjuvant E5103 breast cancer trial. In addition, presentations at major scientific meetings have contributed to biomarker development in breast cancer, including oral presentations at the 2008 ASCO Breast Cancer Symposium, 2009 San Antonio Breast Cancer Symposium, and 2009 ASCO meeting. Furthermore, the APL Core Laboratory at Einstein (R. Gallagher) has supported ECOG's translational research, and the Einstein Center for Epigenomics (J. Greally) is positioned to play a major role in the next funding period. The principal investigator of this application (J. Sparano) also pays a key administrative role in ECOG as an Executive Committee member, Associate Chair for Disease and Modality Oriented Research, Vice- Chair of the Breast Committee, TAILORx study chair, and program chair for the annual ECOG Young Investigator's Symposium. Finally, the recent recruitment Dr. Steven Libutti will serve to expand the surgical oncology program and draw more patients to Einstein, and of Dr. Bruce Rapkin will serve to enhance accrual by integrating clinical trials into the spectrum of standard care. In addition, Dr. Perez-Soler was recently awarded a K12 Calabresi grant which will support the recruitment of additional junior medical oncology faculty members engaged in clinical research.
To provide clinical scientific leadership and resources critical for achieving the Eastern Cooperative Oncology Group (ECOG) mission of reducing cancer-related morbidity and mortality by improving the management of early- and advanced-stage carreer.
|Kernstine, Kemp H; Moon, James; Kraut, Michael J et al. (2014) Trimodality therapy for superior sulcus non-small cell lung cancer: Southwest Oncology Group-Intergroup Trial S0220. Ann Thorac Surg 98:402-10|
|Wilson, Melissa A; Zhao, Fengmin; Letrero, Richard et al. (2014) Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib. Clin Cancer Res 20:3328-37|
|Roberts, Kathryn G; Li, Yongjin; Payne-Turner, Debbie et al. (2014) Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 371:1005-15|
|Andreopoulou, Eleni; Sparano, Joseph A (2013) Chemotherapy in Patients with Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer: An Overview. Curr Breast Cancer Rep 5:42-50|
|Litzow, Mark R; Othus, Megan; Cripe, Larry D et al. (2010) Failure of three novel regimens to improve outcome for patients with relapsed or refractory acute myeloid leukaemia: a report from the Eastern Cooperative Oncology Group. Br J Haematol 148:217-25|
|Wiernik, Peter H; Dutcher, Janice P; Yao, Xiapan et al. (2010) Phase II study of interleukin-4 in indolent B-cell non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E5Y92). J Immunother 33:1006-9|
|Cripe, Larry D; Uno, Hajime; Paietta, Elisabeth M et al. (2010) Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood 116:4077-85|
|Wolff, Antonio C; Wang, Molin; Li, Hailun et al. (2010) Phase II trial of pegylated liposomal doxorubicin plus docetaxel with and without trastuzumab in metastatic breast cancer: Eastern Cooperative Oncology Group trial E3198. Breast Cancer Res Treat 121:111-20|
|Wiernik, Peter H; Hong, Fangxin; Glick, John H et al. (2009) Radiation therapy compared with chemotherapy for consolidation of chemotherapy-induced remission of advanced Hodgkin lymphoma: a study by the Eastern Co-operative Oncology Group (E1476) with >20 years follow-up. Leuk Lymphoma 50:1632-41|
|Sparano, Joseph A; Goldstein, Lori J; Childs, Barrett H et al. (2009) Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer. Clin Cancer Res 15:7693-7700|
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