This application is submitted on behalf of the AECC in order to request continued funding via the U10 mechanism as a main institutional member of the Eastern Cooperative Oncology Group (ECOG). Einstein faculty members play key scientific and administrative leadership roles in ECOG, and accrue a large number of minority subjects and women. The Einstein Cancer Center is an NCI-designated Cancer Center that has been continuously funded since 1971, and is currently funded until July 2012 (P30 CA13330). During the last five year funding period ending 4/30/09, Einstein and its affiliates accrued a total of 604 patients into cancer clinical trials via the ECOG mechanism, including 229 therapeutic accruals from the main institution. Moreover, 64% of all subjects enrolled at the main institution were minority subjects. Einstein faculty members have provided scientific leadership in the breast (J. Sparano), lung (R. Perez-Soler), leukemia (R. Gallagher, A. Verma), head/neck (M. Haigentz), thoracic surgery (S. Keller), and Gl (L. Rajdev) committees. Einstein-affiliated investigators have authored or co-authored 28 manuscripts and 69 abstracts related to ECOG studies, including publications that have influenced the standard of care for operable breast cancer (E1199 - NEJM, 2008) and influenced choice of the standard adjuvant chemotherapy for the ongoing adjuvant E5103 breast cancer trial. In addition, presentations at major scientific meetings have contributed to biomarker development in breast cancer, including oral presentations at the 2008 ASCO Breast Cancer Symposium, 2009 San Antonio Breast Cancer Symposium, and 2009 ASCO meeting. Furthermore, the APL Core Laboratory at Einstein (R. Gallagher) has supported ECOG's translational research, and the Einstein Center for Epigenomics (J. Greally) is positioned to play a major role in the next funding period. The principal investigator of this application (J. Sparano) also pays a key administrative role in ECOG as an Executive Committee member, Associate Chair for Disease and Modality Oriented Research, Vice- Chair of the Breast Committee, TAILORx study chair, and program chair for the annual ECOG Young Investigator's Symposium. Finally, the recent recruitment Dr. Steven Libutti will serve to expand the surgical oncology program and draw more patients to Einstein, and of Dr. Bruce Rapkin will serve to enhance accrual by integrating clinical trials into the spectrum of standard care. In addition, Dr. Perez-Soler was recently awarded a K12 Calabresi grant which will support the recruitment of additional junior medical oncology faculty members engaged in clinical research.

Public Health Relevance

To provide clinical scientific leadership and resources critical for achieving the Eastern Cooperative Oncology Group (ECOG) mission of reducing cancer-related morbidity and mortality by improving the management of early- and advanced-stage carreer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10CA014958-38S1
Application #
8651972
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
Project Start
1978-06-01
Project End
2014-02-28
Budget Start
2013-05-01
Budget End
2014-02-28
Support Year
38
Fiscal Year
2013
Total Cost
$144,167
Indirect Cost
$5,664
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Kumar, Anita J; Gimotty, Phyllis A; Gelfand, Joel et al. (2016) Delays in postremission chemotherapy for Philadelphia chromosome negative acute lymphoblastic leukemia are associated with inferior outcomes in patients who undergo allogeneic transplant: An analysis from ECOG 2993/MRC UK ALLXII. Am J Hematol 91:1107-1112
Wilson, Melissa A; Zhao, Fengmin; Khare, Sanika et al. (2016) Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma. Clin Cancer Res 22:374-82
Haas, Naomi B; Manola, Judith; Uzzo, Robert G et al. (2016) Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet 387:2008-16
Ganzel, Chezi; Manola, Judith; Douer, Dan et al. (2016) Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008. J Clin Oncol 34:3544-3553
Kleinberg, Lawrence R; Catalano, Paul J; Forastiere, Arlene A et al. (2016) Eastern Cooperative Oncology Group and American College of Radiology Imaging Network Randomized Phase 2 Trial of Neoadjuvant Preoperative Paclitaxel/Cisplatin/Radiation Therapy (RT) or Irinotecan/Cisplatin/RT in Esophageal Adenocarcinoma: Long-Term Outcom Int J Radiat Oncol Biol Phys 94:738-46
Walter, R B; Othus, M; Paietta, E M et al. (2015) Effect of genetic profiling on prediction of therapeutic resistance and survival in adult acute myeloid leukemia. Leukemia 29:2104-7
Schneider, Bryan P; Li, Lang; Radovich, Milan et al. (2015) Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199. Clin Cancer Res 21:5082-91
Lucas, David M; Ruppert, Amy S; Lozanski, Gerard et al. (2015) Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: a long-term follow-up study of the US intergr Leuk Lymphoma 56:3031-7
Adams, Sylvia; Gray, Robert J; Demaria, Sandra et al. (2014) Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol 32:2959-66
Zeidan, Amer M; Lee, Ju-Whei; Prebet, Thomas et al. (2014) Platelet count doubling after the first cycle of azacitidine therapy predicts eventual response and survival in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukaemia but does not add to prognostic utility of the revised IPSS. Br J Haematol 167:62-8

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