The Gynecologic Oncology Group (GOG) is the foremost multidisciplinary cooperative clinical trial research group devoted to the study of gynecologic malignancies. Since its inception in 1970, the GOG has been a recognized leader in the development of new forms of treatment and has relied on Phase III trials as the design to identity new standards of care for cancers of the female genital tract, in particular ovarian carcinoma, carcinoma of the uterine cervix, and endometrial carcinoma. Supporting that major activity are the concerted efforts of special studies committees focusing on translational research, developmental therapeutics, quality of life, and cancer prevention and control;and modality committees providing recent approaches and procedures in each of the relevant diagnostic and therapeutic disciplines. The GOG has an active, effective program in the study of new surgical and radiation approaches as well as new systemic agents. In patients with advanced ovarian cancers, GOG studies have defined the current standard of care of cytoreductlve surgery followed by systemic therapy including a taxane and a platinum compound. Current studies seek to improve on this standard with trials of intraperitoneal therapy, targeted agents, and maintenance therapy for those in complete remission. In patients with carcinoma of the cervix, GOG studies have identified new chemotherapeutic agents and combinations for use in the setting of advanced or recurrent disease and have set the standard of care for earlier stage cervix cancer (FIGO stages IB-IVA) as concurrent, cisplatin-based chemoradiation. Current and planned investigations will explore better chemoradiation combinations and the role of targeted agents such as bevacizumab. In patients with endometrial carcinoma, GOG studies have changed the paradigm for the management of advanced or recurrent disease by defining roles for chemotherapy in this difficult patient population. The GOG also has an active effort in less common gynecologic malignancies including uterine sarcomas, gestational trophoblastic disease, germ cell tumors of the ovary, vulvar cancer, among others. Making all of this effort to improve the standard of care possible is an active and extensive effort to identity new approaches through developmental therapeutics and to develop a better understanding of the biology of these malignancies through an active and extensive translational research program. After more than 39 years, the GOG continues to be foremost in developing new strategies for managing these cancers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
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Gynecologic Oncology Group
United States
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(2016) Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun 7:12675
Monk, Bradley J; Sill, Michael W; Walker, Joan L et al. (2016) Randomized Phase II Evaluation of Bevacizumab Versus Bevacizumab Plus Fosbretabulin in Recurrent Ovarian, Tubal, or Peritoneal Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study. J Clin Oncol 34:2279-86
Winder, Abigail D; Maniar, Kruti P; Wei, Jian-Jun et al. (2016) Synuclein-γ in uterine serous carcinoma impacts survival: An NRG Oncology/Gynecologic Oncology Group study. Cancer :
(2016) No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecol Oncol 141:386-401
Myers, Andrea P; Filiaci, Virginia L; Zhang, Yuping et al. (2016) Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol 141:43-8
Hibler, Elizabeth A; Kauderer, James; Greene, Mark H et al. (2016) Bone loss after oophorectomy among high-risk women: an NRG oncology/gynecologic oncology group study. Menopause 23:1228-1232
(2016) Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res 18:64
Eskander, Ramez N; Ali, Shamshad; Dellinger, Thanh et al. (2016) Expression Patterns of the Wnt Pathway Inhibitors Dickkopf3 and Secreted Frizzled-Related Proteins 1 and 4 in Endometrial Endometrioid Adenocarcinoma: An NRG Oncology/Gynecologic Oncology Group Study. Int J Gynecol Cancer 26:125-32
Norquist, Barbara M; Harrell, Maria I; Brady, Mark F et al. (2016) Inherited Mutations in Women With Ovarian Carcinoma. JAMA Oncol 2:482-90
Burton, Elizabeth R; Brady, Mark; Homesley, Howard D et al. (2016) A phase II study of paclitaxel for the treatment of ovarian stromal tumors: An NRG Oncology/ Gynecologic Oncology Group Study. Gynecol Oncol 140:48-52

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