The Fox Chase Cancer Center (FCCC) demonstrates a continued commitment to clinical cancer research through administrative and scientific involvement with the Eastern Cooperative Oncology Group (ECOG). Participation in the ECOG clinical research programs is an integral component of the cancer research performed at FCCC. Active participation in ECOG activities provides an opportunity for our patients to participate in controlled multidisciplinary trials which are designed to provide the best potential new therapies for a variety of different types of cancer. In turn, FCCC performs an important role in defining the merits of these new therapies. ECOG also provides an important opportunity for the Developmental Therapeutics Molecular Medical program at our Center to interact with a larger number of clinical investigators interested in testing new and innovative therapies to improve survival and increase the cure rate for many different cancers. The Cooperative Group Outreach Program (CGOP) provides the opportunity to support our active affiliates, and their critical data management and nurse oncology functions. Through this program we make available to the community the most current therapeutic options and in turn these treatments are tested in the environment in which they will be most widely applied. The primary objectives of this grant are to (1) maintain a level of accrual to ECOG studies;(2) increase the level of multidisciplinary involvement by integrating key modality-oriented individuals into ECOG activity In our affiliate institutions;(3) Increase our contribution to the scientific activities of ECOG, and (4) maintain a high level of scientific and administrative Involvement In ECOG programs. During the next 6 year period, we anticipate growth In our ECOG accrual and In the impact we have on the scientific activities of the Group.

Public Health Relevance

The funding of this grant to Fox Chase Cancer Center (FCCC) provides opportunities for advancement of novel therapeutics to be evaluated in controlled clinical trials. The Eastern Cooperative Oncology Group (ECOG) is the sum of its component cancer center members. The scientific rationale, protocol development and accrual depend on the contribution of the investigators at FCCC. Taken together this will promote the development of new therapies to improve the outcomes for patients with malignancies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA027525-34
Application #
8259811
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
Project Start
1979-06-01
Project End
2016-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
34
Fiscal Year
2012
Total Cost
$408,206
Indirect Cost
$206,083
Name
Fox Chase Cancer Center
Department
Type
DUNS #
073724262
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
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Haas, Naomi B; Manola, Judith; Uzzo, Robert G et al. (2016) Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet 387:2008-16
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Zeidan, Amer M; Lee, Ju-Whei; Prebet, Thomas et al. (2014) Platelet count doubling after the first cycle of azacitidine therapy predicts eventual response and survival in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukaemia but does not add to prognostic utility of the revised IPSS. Br J Haematol 167:62-8
Chang, Julie E; Li, Hailun; Smith, Mitchell R et al. (2014) Phase 2 study of VcR-CVAD with maintenance rituximab for untreated mantle cell lymphoma: an Eastern Cooperative Oncology Group study (E1405). Blood 123:1665-73
Zeidan, Amer M; Lee, Ju-Whei; Prebet, Thomas et al. (2014) Comparison of the prognostic utility of the revised International Prognostic Scoring System and the French Prognostic Scoring System in azacitidine-treated patients with myelodysplastic syndromes. Br J Haematol 166:352-9
Sanford, Stacy D; Zhao, Fengmin; Salsman, John M et al. (2014) Symptom burden among young adults with breast or colorectal cancer. Cancer 120:2255-63

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