The University of Iowa Hospitals & Clinics is the nation's largest university-owned teaching hospital with specialized care provided by more than 1400 physicians and 1500 registered nurses, and serves more than 450,000 patients annually. The University of Iowa Cancer Center facilitates interdisciplinary research, clinical and educational activities of faculty and staff among 15 multidisciplinary clinical cancer programs. The Pediatric Cancer multidisciplinary team is directed by a recently expanded Hematology/Oncology Division consisting of 8 oncologists, 2 data managers, 3 physician assistants, 3 oncology nurses, and supported by 66 specialty professionals from 13 departments. A computerized protocol system that facilitates communication, data collection, and continuous audit of protocol compliance, has been used to integrate the primary, secondary and tertiary health care systems of the region into a shared management network to better serve our rural area. Iowa investigators have shaped CCG research in acute lymphocytic leukemia, germ cell tumors, Wilms' tumor, and psychology. They chair or actively participate in the in the ALL Strategy Committee, the Soft Tissue Tumor Strategy Committee, the Wilms' Tumor Strategy Committee, and the Psychology Committee. They chair 3 study committees, have piloted 3 studies, the concepts of which have been accepted by the Group, have organized CCG scientific meetings, and contribute to the scientific and administrative functions of 38 CCG committees. Study entry of eligible patients has been greater than 93%. Data collection has been accurate and timely as demonstrated by our consistently high ratings among CCG institutions for data submissions, pathology submissions, pathology reviews, and by The University of Iowa being the only institution to have a """"""""perfect"""""""" on-site audit. Our goals are:1) to maintain the highest quality protocol compliance and data submission, 2) to provide more leadership and increase participation in CCG scientific and executive activities, pilot clinical and basic research concepts, and submit current and future concepts for group-wide studies, and 3) to provide CCG with a regional lmmunopathology Reference Laboratory.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA029314-18
Application #
2607998
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Program Officer
Kaplan, Richard S
Project Start
1980-12-15
Project End
1998-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Iowa
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Neudorf, Steven; Sanders, Jean; Kobrinsky, Nathan et al. (2004) Allogeneic bone marrow transplantation for children with acute myelocytic leukemia in first remission demonstrates a role for graft versus leukemia in the maintenance of disease-free survival. Blood 103:3655-61
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Lange, Beverly J; Bostrom, Bruce C; Cherlow, Joel M et al. (2002) Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 99:825-33
Ou, Shu Xiao; Han, Dehui; Severson, Richard K et al. (2002) Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 13:15-25
Cairo, M S; Krailo, M D; Morse, M et al. (2002) Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia 16:594-600
Wells, R J; Arthur, D C; Srivastava, A et al. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-7
Cooper, R; Khakoo, Y; Matthay, K K et al. (2001) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features-a report from the Children's Cancer Group. Med Pediatr Oncol 36:623-9
Sposto, R; Meadows, A T; Chilcote, R R et al. (2001) Comparison of long-term outcome of children and adolescents with disseminated non-lymphoblastic non-Hodgkin lymphoma treated with COMP or daunomycin-COMP: A report from the Children's Cancer Group. Med Pediatr Oncol 37:432-41