This application represents the first joint application of the newly formed ECOG/ACRIN alliance to build upon ECOG's long history as a successful Community Clinical Oncology Program (CCOP) Research Base. The ECOG and ACRIN leadership recognize the opportunity to strengthen their mutual scientific programs, ECOG Cancer Prevention and Control research base with ACRIN's complementary expertise in early detection, imaging diagnosis, and cost and comparative effectiveness organizations, are proposing a bold, integrated cancer prevention and control scientific program. The program will have two major foci: (1) Patient-Centered Outcomes and Survivorship and (2) Early Detection, Diagnosis and Prevention.
Specific Aims of the program: 1)To develop personalized early detection strategies to reduce false positives and improve screening outcomes;2)To contribute to state-of-the-science research in patient centered outcomes and health care related cost measurement and analysis in the context of cancer clinical trials;3)To enroll patients onto high-quality, meaningful prevention and symptom management trials that add to our understanding of the prevention or elimination of suffering attributable to cancer;4)To advance our understanding of cancer survivorship and design interventions to address related issues;5)To develop biomarker-driven chemoprevention trials based on state-of the-science preclinical data that ultimately translate into national trials through the ECOG prevention group and CCOP members;6)To continue to develop treatment protocols particularly suitable for the CCOP members of ECOG and their patients;7)To expand development of programs to increase the accrual of minority populations to ECOG trials with a focus on disparity intervention;8)To improve support for protocol development, data management, and analysis by enhancing the dedicated infrastructure within the ECOG Coordinating Center for the cancer control and prevention program to include cost effectiveness methodology;and 9)To foster collaboration between scientific committees and the Patient-Centered Outcomes and Survivorship Committee and the Early Detection, Diagnosis and Prevention Committee.
|Fisch, Michael J; Zhao, Fengmin; Manola, Judith et al. (2015) Patterns and predictors of antidepressant use in ambulatory cancer patients with common solid tumors. Psychooncology 24:523-32|
|Jones, Desiree; Zhao, Fengmin; Brell, Joanna et al. (2015) Neuropathic symptoms, quality of life, and clinician perception of patient care in medical oncology outpatients with colorectal, breast, lung, and prostate cancer. J Cancer Surviv 9:10-Jan|
|Pradhan, Kamnesh R; Stump, Timothy E; Monahan, Patrick et al. (2015) Relationships among attention function, exercise, and body mass index: a comparison between young breast cancer survivors and acquaintance controls. Psychooncology 24:325-32|
|Wang, Xin Shelley; Zhao, Fengmin; Fisch, Michael J et al. (2014) Prevalence and characteristics of moderate to severe fatigue: a multicenter study in cancer patients and survivors. Cancer 120:425-32|
|Zhao, Fengmin; Chang, Victor T; Cleeland, Charles et al. (2014) Determinants of pain severity changes in ambulatory patients with cancer: an analysis from Eastern Cooperative Oncology Group trial E2Z02. J Clin Oncol 32:312-9|
|Fisch, Michael J; Zhao, Fengmin; O'Mara, Ann M et al. (2014) Predictors of significant worsening of patient-reported fatigue over a 1-month timeframe in ambulatory patients with common solid tumors. Cancer 120:442-50|
|Jones, Desiree; Zhao, Fengmin; Fisch, Michael J et al. (2014) The validity and utility of the MD Anderson Symptom Inventory in patients with prostate cancer: evidence from the Symptom Outcomes and Practice Patterns (SOAPP) data from the Eastern Cooperative Oncology Group. Clin Genitourin Cancer 12:41-9|
|Champion, Victoria L; Wagner, Lynne I; Monahan, Patrick O et al. (2014) Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains. Cancer 120:2237-46|
|Pillai, Rathi N; Aisner, Joseph; Dahlberg, Suzanne E et al. (2014) Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501). Cancer Chemother Pharmacol 74:177-83|
|Sanford, Stacy D; Zhao, Fengmin; Salsman, John M et al. (2014) Symptom burden among young adults with breast or colorectal cancer. Cancer 120:2255-63|
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