This application represents the first joint application of the newly formed ECOG/ACRIN alliance to build upon ECOG's long history as a successful Community Clinical Oncology Program (CCOP) Research Base. The ECOG and ACRIN leadership recognize the opportunity to strengthen their mutual scientific programs, ECOG Cancer Prevention and Control research base with ACRIN's complementary expertise in early detection, imaging diagnosis, and cost and comparative effectiveness organizations, are proposing a bold, integrated cancer prevention and control scientific program. The program will have two major foci: (1) Patient-Centered Outcomes and Survivorship and (2) Early Detection, Diagnosis and Prevention.
Specific Aims of the program: 1)To develop personalized early detection strategies to reduce false positives and improve screening outcomes;2)To contribute to state-of-the-science research in patient centered outcomes and health care related cost measurement and analysis in the context of cancer clinical trials;3)To enroll patients onto high-quality, meaningful prevention and symptom management trials that add to our understanding of the prevention or elimination of suffering attributable to cancer;4)To advance our understanding of cancer survivorship and design interventions to address related issues;5)To develop biomarker-driven chemoprevention trials based on state-of the-science preclinical data that ultimately translate into national trials through the ECOG prevention group and CCOP members;6)To continue to develop treatment protocols particularly suitable for the CCOP members of ECOG and their patients;7)To expand development of programs to increase the accrual of minority populations to ECOG trials with a focus on disparity intervention;8)To improve support for protocol development, data management, and analysis by enhancing the dedicated infrastructure within the ECOG Coordinating Center for the cancer control and prevention program to include cost effectiveness methodology;and 9)To foster collaboration between scientific committees and the Patient-Centered Outcomes and Survivorship Committee and the Early Detection, Diagnosis and Prevention Committee.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10CA037403-28S1
Application #
8851889
Study Section
Special Emphasis Panel (ZCA1-SRLB-B (J1))
Program Officer
Brell, Joanna M
Project Start
1992-09-01
Project End
2014-07-31
Budget Start
2013-06-01
Budget End
2014-07-31
Support Year
28
Fiscal Year
2014
Total Cost
$576,846
Indirect Cost
$2,968
Name
Drexel University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tevaarwerk, Amye J; Lee, Ju-Whei; Terhaar, Abigail et al. (2016) Working after a metastatic cancer diagnosis: Factors affecting employment in the metastatic setting from ECOG-ACRIN's Symptom Outcomes and Practice Patterns study. Cancer 122:438-46
Moots, Paul L; O'Neill, Anne; Londer, Harold et al. (2016) Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397). Am J Clin Oncol :
Cohee, Andrea A; Adams, Rebecca N; Johns, Shelley A et al. (2015) Long-term fear of recurrence in young breast cancer survivors and partners. Psychooncology :
Lewis, Mark A; Zhao, Fengmin; Jones, Desiree et al. (2015) Neuropathic Symptoms and Their Risk Factors in Medical Oncology Outpatients With Colorectal vs. Breast, Lung, or Prostate Cancer: Results From a Prospective Multicenter Study. J Pain Symptom Manage 49:1016-24
Fisch, Michael J; Zhao, Fengmin; Manola, Judith et al. (2015) Patterns and predictors of antidepressant use in ambulatory cancer patients with common solid tumors. Psychooncology 24:523-32
Sparano, Joseph A; Gray, Robert J; Makower, Della F et al. (2015) Prospective Validation of a 21-Gene Expression Assay in Breast Cancer. N Engl J Med 373:2005-14
Minasian, Lori M; Tangen, Catherine M; Wickerham, D Lawrence (2015) Ongoing Use of Data and Specimens From National Cancer Institute-Sponsored Cancer Prevention Clinical Trials in the Community Clinical Oncology Program. Semin Oncol 42:748-63
Jones, Desiree; Zhao, Fengmin; Brell, Joanna et al. (2015) Neuropathic symptoms, quality of life, and clinician perception of patient care in medical oncology outpatients with colorectal, breast, lung, and prostate cancer. J Cancer Surviv 9:1-10
Sweeney, Christopher J; Chen, Yu-Hui; Carducci, Michael et al. (2015) Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer. N Engl J Med 373:737-46
Wagner, Lynne I; Zhao, Fengmin; Hong, Fangxin et al. (2015) Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: results from ECOG trial E4402 (RESORT). J Clin Oncol 33:740-8

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