The Mayo Clinic, through the vehicle of the North Central Cancer Treatment Group (NCCTG) and, increasingly, through the Alliance for Clinical Trials in Oncology (aka, Alliance or ACTION), will serve as a primary research base for the 34 CCOPs with current NCCTG affiliations, providing both treatment and cancer control trials. We will also serve as a research base for cancer control and treatment protocol activity of non-CCOP members of the NCCTG. We will cooperate with our affiliated CCOPs and other members in conducting appropriate continuing education and workshops. The research base will provide training and active support for their data managers/research associates and oncology nurses. We will coordinate their multidisciplinary involvement in clinical cancer research protocols. By group meetings involving NCCTG and Alliance members, we will facilitate the review of ongoing research, plan future research and conduct related professional activities. The research bases will continue the rigid quality control procedures which have proved so successful in the past, and upgrade these procedures as indicated. We will constantly monitor CCOP and member performance, not only by timely review of patient accrual, data sheets, pathology material, operative reports, and radiation therapy port films, but also by periodic, randomly-scheduled monitoring site visits. The research bases will work with investigators and members in preparing publications as well as presentations for national and regional meetings. We will make every effort to provide members with reasons to be proud of their participation in the National Cancer Program. Our focus, over this grant period, will be on the further expansion of our cancer control efforts to include high priority symptoms adversely affecting completion of cancer treatment as well as survivorship quality, cancer prevention, and screening. We will incorporate associated basic laboratory support, leading to scientifically rigorous translational research efforts. Lastly, we will strive to meld ourselves, with two other current cooperative oncology groups (CALGB and ACOSOG) to become one Alliance group to continue the efforts described in this current grant proposal.

Public Health Relevance

This project is very relevant to public health as cancer is such a large clinical problem leading to substantial disability and death. This program will define optimal means for controlling symptoms related to cancer and/or cancer therapy along with investigating methods to detect cancer early and prevent cancer. It will involve academic medical centers and also non-academic cancer clinical practice sites.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA037404-27
Application #
8308106
Study Section
Special Emphasis Panel (ZCA1-SRLB-B (J1))
Program Officer
Kelaghan, Joseph
Project Start
1983-09-15
Project End
2015-05-31
Budget Start
2012-08-01
Budget End
2013-05-31
Support Year
27
Fiscal Year
2012
Total Cost
$2,867,539
Indirect Cost
$1,231,974
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Kottschade, Lisa; Novotny, Paul; Lyss, Alan et al. (2016) Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance). Support Care Cancer 24:2661-7
Kadakia, Kunal C; Loprinzi, Charles L; Atherton, Pamela J et al. (2016) Phase II evaluation of S-adenosyl-L-methionine (SAMe) for the treatment of hot flashes. Support Care Cancer 24:1061-9
Sio, Terence T; Atherton, Pamela J; Birckhead, Brandon J et al. (2016) Repeated measures analyses of dermatitis symptom evolution in breast cancer patients receiving radiotherapy in a phase 3 randomized trial of mometasone furoate vs placebo (N06C4 [alliance]). Support Care Cancer 24:3847-55
Liu, Xiaonan; Li, Jing; Wu, Teresa et al. (2016) Patient Specific Characteristics Are an Important Factor That Determines the Risk of Acute Grade ≥ 2 Rectal Toxicity in Patients Treated for Prostate Cancer with IMRT and Daily Image Guidance Based on Implanted Gold Markers. OMICS J Radiol 5:
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Zimmerman, Collin; Atherton, Pamela J; Pachman, Deirdre et al. (2016) MC11C4: a pilot randomized, placebo-controlled, double-blind study of venlafaxine to prevent oxaliplatin-induced neuropathy. Support Care Cancer 24:1071-8
Miller, Robert C; Petereit, Daniel G; Sloan, Jeff A et al. (2016) N08C9 (Alliance): A Phase 3 Randomized Study of Sulfasalazine Versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy. Int J Radiat Oncol Biol Phys 95:1168-74
Crozier, Jennifer A; Advani, Pooja P; LaPlant, Betsy et al. (2016) N0436 (Alliance): A Phase II Trial of Irinotecan With Cetuximab in Patients With Metastatic Breast Cancer Previously Exposed to Anthracycline and/or Taxane-Containing Therapy. Clin Breast Cancer 16:23-30
Park, Haeseong; Qin, Rui; Smith, Thomas J et al. (2015) North Central Cancer Treatment Group N10C2 (Alliance): a double-blind placebo-controlled study of magnesium supplements to reduce menopausal hot flashes. Menopause 22:627-32
Liu, Heshan; Tan, Angelina D; Qin, Rui et al. (2015) Comparing and Validating Simple Measures of Patient-Reported Peripheral Neuropathy for Oncology Clinical Trials: NCCTG N0897 (Alliance) A Pooled Analysis of 2440 Patients. SOJ Anesthesiol Pain Manag 2:

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