The Statistics and Data Center (SDC) of the Children's Oncology Group (COG) serve two important, distinct but related functions in COG. The first is to provide statistical sciences expertise in support of COG research through a staff of experienced Ph.D. level statisticians who are faculty members at major universities. These 'faculty' statisticians collaborate with COG investigators through their membership on COG study and scientific committees. They are assisted in this function by master-level statisticians and programmers who are also employed by the SDC. The second important function of the SDC is study and data operations - i.e., the coordination of COG research studies and the timely acquisition and storage of high quality data for COG studies, and interaction with COG institutions and study committees to ensure successful completion of COG studies. A staff of information technology professionals and research coordinators accomplish this SDC function. The COG SDC consist of two logically distinct departments or divisions: The first is the statistics department, which comprises the senior (Ph.D.) statisticians and assistant (M.S.) statisticians, plus some support staff. Although functioning as a united department, the members of this department are located at four main sites: The University of Southern California (USC)/Arcadia, the University of Nebraska/Omaha, the University of Florida/Gainesville and the University of Washington. The second division is data operations. This includes the Information Systems (IS) and computing staff which supports Remote Data Entry (RDE) and other necessary computing functions. All IS and computing staff will ultimately be located in Arcadia, although for the first two years of the grant period a small number will remain in Gainesville until the consolidation in Arcadia is complete. The division also includes a staff of research coordinators, who serve as the primary managers of studies and study data in the SDC, and who serve as the primary interface between the study committees, institutions, statisticians, the study development office and Group leadership, for all matters concerning data collection and related issues for ongoing COG studies. This staff is directed by a lead research coordinator who reports to the Group Statistician.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA098413-04
Application #
7013792
Study Section
Subcommittee G - Education (NCI)
Program Officer
Smith, Malcolm M
Project Start
2003-06-20
Project End
2008-02-29
Budget Start
2006-06-29
Budget End
2007-02-28
Support Year
4
Fiscal Year
2006
Total Cost
$6,066,063
Indirect Cost
Name
National Childhood Cancer Foundation
Department
Type
DUNS #
624124301
City
Arcadia
State
CA
Country
United States
Zip Code
91006
Mullen, Elizabeth A; Chi, Yueh-Yun; Hibbitts, Emily et al. (2018) Impact of Surveillance Imaging Modality on Survival After Recurrence in Patients With Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group. J Clin Oncol :JCO1800076
Laetsch, Theodore W; Roy, Angshumoy; Xu, Lin et al. (2018) Undifferentiated Sarcomas in Children Harbor Clinically Relevant Oncogenic Fusions and Gene Copy-Number Alterations: A Report from the Children's Oncology Group. Clin Cancer Res 24:3888-3897
Barredo, Julio C; Hastings, Caroline; Lu, Xiamin et al. (2018) Isolated late testicular relapse of B-cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response-based testicular radiation: A Children's Oncology Group study. Pediatr Blood Cancer 65:e26928
Marks, Lianna J; Pei, Qinglin; Bush, Rizvan et al. (2018) Outcomes in intermediate-risk pediatric lymphocyte-predominant Hodgkin lymphoma: A report from the Children's Oncology Group. Pediatr Blood Cancer 65:e27375
Hawkins, Douglas S; Chi, Yueh-Yun; Anderson, James R et al. (2018) Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group. J Clin Oncol 36:2770-2777
Burns, Melissa A; Liao, Zi Wei; Yamagata, Natsuko et al. (2018) Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia 32:2126-2137
Bolouri, Hamid; Farrar, Jason E; Triche Jr, Timothy et al. (2018) The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med 24:103-112
Dvorak, Christopher C; Satwani, Prakash; Stieglitz, Elliot et al. (2018) Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study. Pediatr Blood Cancer 65:e27034
Alexander, Thomas B; Gu, Zhaohui; Iacobucci, Ilaria et al. (2018) The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature 562:373-379
Dix, David B; Seibel, Nita L; Chi, Yueh-Yun et al. (2018) Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children's Oncology Group AREN0533 Study. J Clin Oncol 36:1564-1570

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