Heartland CCOP performs the following activities: 1) enrolls significant numbers of participants to federally-sponsored cancer treatment trials, 2) recruits participants to NCI-sponsored cancer prevention and control studies, 3) participates in cancer screening/early diagnosis clinics and provides education about cancer prevention strategies, 4) educates the public and professional colleagues about cancer research and raises the visibility of NCI trials, 5) participates actively in NCI-sponsored cooperative group life, quality assurance and science. Heartland's two component institutions, Missouri Baptist Medical Center (MBMC) and the Center for Cancer Care and Research (CCCR) each have a long history of high-quality clinical oncology research. The components of that research include: 1) 12 medical oncologists and associated professional staff with clinical trial experience, 2) diligent protection of human subjects according to federal regulations, 3) established, successful participant eligibility screening procedures, and 4) refined protocol and data management procedures. In addition to their accrual and data management efforts, Heartland members have expanded their contributions to the group life of CALGB, NSABP and NCCTG. Heartland continues to expand the existing research program to offer clinical research access to a wide geographic area, as well augmenting the cancer related health of the suburban and rural communities served by the CCOP. The Heartland Research Consortium (Heartland) was developed to reduce cancer incidence, morbidity, and mortality by accelerating the transfer of newly developed cancer prevention and cancer treatment interventions to the populace of St. Louis County and contiguous, medically under-served rural areas in eastern Missouri. In addition to three main offices in West St. Louis County, Heartland maintains four rural outreach clinics. Through these offices and outreach clinics, Heartland provides hematology and oncology services and clinical research access to a total of ten counties in eastern Missouri that would not otherwise be available.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZCA1-SRRB-Y (J1))
Program Officer
Kelaghan, Joseph
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Missouri Baptist Medical Center
St. Louis
United States
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Heist, Rebecca S; Wang, Xiaofei; Hodgson, Lydia et al. (2014) CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer. J Thorac Oncol 9:214-21
Du, Juan; Lopez-Verges, Sandra; Pitcher, Brandelyn N et al. (2014) CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. Cancer Immunol Res 2:878-89
Aggarwal, Rahul; Halabi, Susan; Kelly, William Kevin et al. (2013) The effect of prior androgen synthesis inhibition on outcomes of subsequent therapy with docetaxel in patients with metastatic castrate-resistant prostate cancer: results from a retrospective analysis of a randomized phase 3 clinical trial (CALGB 90401) ( Cancer 119:3636-43
Romanus, Dorothy; Kindler, Hedy L; Archer, Laura et al. (2012) Does health-related quality of life improve for advanced pancreatic cancer patients who respond to gemcitabine? Analysis of a randomized phase III trial of the cancer and leukemia group B (CALGB 80303). J Pain Symptom Manage 43:205-17
Wolf, Sherry L; Qin, Rui; Menon, Smitha P et al. (2010) Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. J Clin Oncol 28:5182-7
Miller, Antonius A; Pang, Herbert; Hodgson, Lydia et al. (2010) A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602). J Thorac Oncol 5:380-4
Yao, Song; Barlow, William E; Albain, Kathy S et al. (2010) Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. Clin Cancer Res 16:6169-76
Lyss, Alan P; Lilenbaum, Rogerio C (2009) Accrual to National Cancer Institute-sponsored non-small-cell lung cancer trials: insights and contributions from the CCOP program. Clin Lung Cancer 10:410-3
Ambrosone, Christine B; Barlow, William E; Reynolds, Wanda et al. (2009) Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897. J Clin Oncol 27:4973-9
Philips, G K; Halabi, S; Sanford, B L et al. (2009) A phase II trial of cisplatin (C), gemcitabine (G) and gefitinib for advanced urothelial tract carcinoma: results of Cancer and Leukemia Group B (CALGB) 90102. Ann Oncol 20:1074-9

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