Indiana University brings multidisciplinary research teams with expertise in translational sciences along with streamlined resources, efficient services, and an institutional environment that fosters innovative clinical and translational research to the NCTN. IU investigators have left trials that defined the standard of care in thymoma, testes, pancreas, and breast cancer. We are committed to leading and supporting the next generation of translational trials within the National Clinical Trial Network. As a Lead Academic Participating Site we will pursue four specific aims: 1) Integrate genomics, pharmacogenomics, and other molecular assays with traditional histopathology to individualize therapy, 2) Lead clinical and translational research in key rare tumors, 3) Use the cooperative groups to further cancer survivorship research, and 4) Mentor junior faculty members. To accomplish those specific aims, we have redesigned and consolidated the clinical trial infrastructure to function with greater efficiency and cost-effectiveness while still meeting the needs of investigators. Overall leadership of the NCTN at lU is vested in Dr. Kathy Miller, a seasoned investigator who has led three national trials coordinated by ECOG. Dr. Miller enjoys widespread institutional and multidisciplinary support and is fully empowered to leverage resources needed to facilitate accrual and movement of IU translational science forward to the NCTN. She is joined by key investigators in Hematology/Oncology, Gynecologic Oncology, Radiation Oncology, Surgery, Pathology, Nursing, and Urology. In this application IU will be joined by four affiliates 1) The Richard A Roudebush VA Medical Center, 2) IU Health Ball Memorial Hospital, 3) IU Health Central Indiana Cancer Centers, and 4) IU Health Goshen. IU accrual averages ~100 patients per year over the most recent 5 year period with participation in ECOG (~65%), GOG (~25%), and ACOSOG (~10%). In addition IU investigators have held key leadership roles within ECOG and the GOG and have made key scientific contributions employing biologic specimens banked as part of cooperative group trials.

Public Health Relevance

The lUSCC is the only NCI-Designated Cancer Center that treats patients in Indiana. Our long standing commitment for clinical research has been illustrated by pilot trials conducted at lUSCC and taken to the cooperative oncology groups (ECOG) for definitive testing. Standards of care for the treatment of germ cell tumors, lung cancer, thymoma and breast cancer have emerged from trials led by IU investigators.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-P (O1))
Program Officer
Mooney, Margaret M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Dickler, Maura N; Barry, William T; Cirrincione, Constance T et al. (2016) Phase III Trial Evaluating Letrozole As First-Line Endocrine Therapy With or Without Bevacizumab for the Treatment of Postmenopausal Women With Hormone Receptor-Positive Advanced-Stage Breast Cancer: CALGB 40503 (Alliance). J Clin Oncol 34:2602-9
Adams, Rebecca N; Mosher, Catherine E; Cohee, Andrea A et al. (2016) Avoidant coping and self-efficacy mediate relationships between perceived social constraints and symptoms among long-term breast cancer survivors. Psychooncology :
Ganzel, Chezi; Manola, Judith; Douer, Dan et al. (2016) Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008. J Clin Oncol 34:3544-3553
Perez, Edith A; Ballman, Karla V; Tenner, Kathy S et al. (2016) Association of Stromal Tumor-Infiltrating Lymphocytes With Recurrence-Free Survival in the N9831 Adjuvant Trial in Patients With Early-Stage HER2-Positive Breast Cancer. JAMA Oncol 2:56-64
Gesselman, Amanda N; Bigatti, Silvia M; Garcia, Justin R et al. (2016) Spirituality, emotional distress, and post-traumatic growth in breast cancer survivors and their partners: an actor-partner interdependence modeling approach. Psychooncology :
Hanna, Nasser H; Dahlberg, Suzanne E; Kolesar, Jill M et al. (2015) Three-arm, randomized, phase 2 study of carboplatin and paclitaxel in combination with cetuximab, cixutumumab, or both for advanced non-small cell lung cancer (NSCLC) patients who will not receive bevacizumab-based therapy: An Eastern Cooperative Oncology Cancer 121:2253-61
Solin, Lawrence J; Gray, Robert; Hughes, Lorie L et al. (2015) Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study. J Clin Oncol 33:3938-44
Sparano, Joseph A; Gray, Robert J; Makower, Della F et al. (2015) Prospective Validation of a 21-Gene Expression Assay in Breast Cancer. N Engl J Med 373:2005-14
Sweeney, Christopher J; Chen, Yu-Hui; Carducci, Michael et al. (2015) Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer. N Engl J Med 373:737-46
Bossuyt, V; Provenzano, E; Symmans, W F et al. (2015) Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration. Ann Oncol 26:1280-91

Showing the most recent 10 out of 20 publications