Johns Hopkins has been an academic member institution of cooperative groups since the founding of this national oncology research in 1955. Over the decades, our faculties have provided strong clinical and laboratory scientific leadership and administrative leadership to the cooperative groups. Our primary goal is to bring innovative translational science developed in pre-clinical and early phase trials at Johns Hopkins to the National Clinical Trials Network for further development. In conjunction with this, our faculties serve in leadership roles as study chairs and laboratory co-chairs, disease and modality-oriented committee chairs. The majority of our contributions and our longest association has been with ECOG (now ECOG-ACRIN) and secondly, with GOG (now NRG).
The specific aims are: 1) To integrate all of the cooperative group activities within one administrative program at Johns Hopkins to foster a coordinated, collaborative and inclusive process of prioritization of trials and the facilitation of trial activation and accrual. 2) To promote participation in innovatve, multi-modality treatments in cancer with a focus on imaging, radiation, surgery, novel systemic therapeutics and biomarkers. 3) To continue to provide scientific leadership in the NCTN groups and there, disease-oriented committees and promote the involvement of junior faculty. 4) To continue to bring correlative translational research, novel imaging and radiation techniques, cell biology and molecular biology into clinical protocols for all stages of disease. 5) To continue to expand accrual, provide efficient and timely trial activation, and to maintain excellent performance in data quality. These goals will be accomplished through the mission of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. The Center has achieved excellence in translational research with the awarding of six SPORE grants (cervix, Gl-cancer, prostate, breast, lung, head and neck). In addition, early clinical trials of new drugs are conducted under the NCI phase 1 contract (since 1982). The Early Therapeutics Development with Phase II Emphasis grants allows the development of laboratory science and imaging correlative studies. The recent expansion of Center facilities enhances clinical trial accrual.
Johns Hopkins has an extraordinary institutional commitment to the health of the public. Through close collaboration, the Cancer Center and the School of Public Health advance the study of not only cancer treatments, but also the early detection, screening, prevention of cancer and its effect on financial stability and quality of life, thus encompassing the overall impact of cancer on the lives of patients.
|Piccart-Gebhart, Martine; Holmes, Eileen; Baselga, JosÃ© et al. (2016) Adjuvant Lapatinib and Trastuzumab for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Trial. J Clin Oncol 34:1034-42|
|Pine, Alexander B; Lee, Eun-Ju; Sekeres, Mikkael et al. (2016) Wide variations in blood product transfusion practices among providers who care for patients with acute leukemia in the United States. Transfusion :|
|Hertz, Daniel L; Owzar, Kouros; Lessans, Sherrie et al. (2016) Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Clin Cancer Res 22:4890-4900|
|Goss, Paul E; Ingle, James N; Pritchard, Kathleen I et al. (2016) Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years. N Engl J Med 375:209-19|
|Lichtman, Stuart M; Cirrincione, Constance T; Hurria, Arti et al. (2016) Effect of Pretreatment Renal Function on Treatment and Clinical Outcomes in the Adjuvant Treatment of Older Women With Breast Cancer: Alliance A171201, an Ancillary Study of CALGB/CTSU 49907. J Clin Oncol 34:699-705|
|Sonnenblick, Amir; de Azambuja, Evandro; Agbor-Tarh, Dominique et al. (2016) Lapatinib-Related Rash and Breast Cancer Outcome in the ALTTO Phase III Randomized Trial. J Natl Cancer Inst 108:|
|Sagae, Satoru; Monk, Bradley J; Pujade-Lauraine, Eric et al. (2016) Advances and Concepts in Cervical Cancer Trials: A Road Map for the Future. Int J Gynecol Cancer 26:199-207|
|Belani, Chandra P; Dahlberg, Suzanne E; Rudin, Charles M et al. (2016) Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508). Cancer 122:2371-8|
|Garcia-Soto, Arlene E; Java, James J; Nieves Neira, Wilberto et al. (2016) Does time interval between surgery and intraperitoneal chemotherapy administration in advanced ovarian cancer carry a prognostic impact? An NRG Oncology/Gynecologic Oncology Group study ancillary study. Gynecol Oncol 143:484-489|
|Majithia, Neil; Temkin, Sarah M; Ruddy, Kathryn J et al. (2016) National Cancer Institute-supported chemotherapy-induced peripheral neuropathy trials: outcomes and lessons. Support Care Cancer 24:1439-47|
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