The mission of the NRG Oncology Statistics and Data Management Center (SDMC) is to provide all necessary expertise and personnel for the design, conduct and analysis of clinical trials and associated research for NRG Oncology, a member group of the NCI National Clinical Trials Network (NCTN) program. The 2019-2024 cycle represents the second period of the NCTN program, which succeeded the NCI Cancer Cooperative Group program and of which NRG Oncology was formed by the unification of three of the Cooperative Groups. NRG Oncology has unique expertise in gender-specific malignancies (breast, gynecologic, and prostate cancer), as well as a major presence in several cancer types (head & neck, lung, brain, upper GI) where radiotherapy has a critical role in conjunction with other modalities. In the first cycle (2014-2019) of the NCTN, the NRG Oncology SDMC and partner Operations Center personnel expended significant effort in successfully transforming into a truly united and highly functioning group. Success in this effort for the SDMC is evident throughout the renewal application. At the same time, the new group made significant strides in advancing cancer treatment, ancillary care, and biologic knowledge, which is also thoroughly in evidence through the clinical/scientific output of NRG Oncology, and through contributions of the SDMC to clinical trials methodology and practice. During the first cycle, the group initiated 32 new trials and obtained final approval on an additional 14 trials that are now in development, while maintaining accrual and/or follow-up to primary and secondary endpoint reporting on over 80 additional trials that were active at the inception of NRG Oncology. Publications from the group to date number over 300, including 39 methodology articles by SDMC statisticians. In the second NCTN period, NRG Oncology anticipates even greater success, and the SDMC is critical to achieving this goal. To carry out its mission, the NRG Oncology SDMC will continue to collaborate closely with NRG Oncology leadership and trial investigators to design and conduct highest quality clinical trials that will yield definitive conclusions. The SDMC will provide continuous trial conduct oversight through all stages from concept inception through protocol development, trial monitoring, initial reporting, and publication. Through its quality assurance program, the SDMC will provide quality control checks across the lifecycle of trials. The SDMC will continue to apply, or develop as needed, innovative statistical designs in all phases of clinical trials, using integrated developmental phases of trials where advantageous, and incorporating modern biomarker based information into trial designs and their attendant analysis plans. The SDMC will continue to Implement state-of-the-art data management and information technology systems to assure secure high-quality data collection, maintenance, and curation for additional discovery and data sharing with the larger research community.

Public Health Relevance

While outcomes have been improved for many cancers, there remains a substantial need to develop and validate more effective treatments, while also improving the quality of life and well-being for cancer patients. The NRG Oncology National Clinical Trials Network (NCTN) group addresses this need, and the NRG Oncology Statistics and Data Management Center (SDMC) represents an integral component critical to ensuring that NRG Oncology clinical trials are properly designed, implemented, conducted, analyzed, and disseminated. This application seeks resources for the NRG Oncology SDMC to support the NRG Oncology and NCTN research agenda for the 2019-2024 program period. !

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA180822-06
Application #
9628261
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Mooney, Margaret M
Project Start
2014-04-18
Project End
2025-02-28
Budget Start
2019-03-28
Budget End
2020-02-29
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Younge, Kelly C; Marsh, Robin B; Owen, Dawn et al. (2018) Improving Quality and Consistency in NRG Oncology Radiation Therapy Oncology Group 0631 for Spine Radiosurgery via Knowledge-Based Planning. Int J Radiat Oncol Biol Phys 100:1067-1074
Lukka, Himanshu R; Pugh, Stephanie L; Bruner, Deborah W et al. (2018) Patient Reported Outcomes in NRG Oncology RTOG 0938, Evaluating Two Ultrahypofractionated Regimens for Prostate Cancer. Int J Radiat Oncol Biol Phys 102:287-295
Lieberman, Frank S; Wang, Meihua; Robins, H Ian et al. (2018) Phase 2 Study of Radiation Therapy Plus Low Dose Temozolomide Followed by Temozolomide and Irinotecan for Glioblastoma: NRG Oncology RTOG Trial 0420. Int J Radiat Oncol Biol Phys :
Felix, A S; Brasky, T M; Cohn, D E et al. (2018) Endometrial carcinoma recurrence according to race and ethnicity: An NRG Oncology/Gynecologic Oncology Group 210 Study. Int J Cancer 142:1102-1115
Geyer Jr, Charles E; Tang, Gong; Mamounas, Eleftherios P et al. (2018) 21-Gene assay as predictor of chemotherapy benefit in HER2-negative breast cancer. NPJ Breast Cancer 4:37
Bell, Erica H; Zhang, Peixin; Fisher, Barbara J et al. (2018) Association of MGMT Promoter Methylation Status With Survival Outcomes in Patients With High-Risk Glioma Treated With Radiotherapy and Temozolomide: An Analysis From the NRG Oncology/RTOG 0424 Trial. JAMA Oncol 4:1405-1409
Norquist, Barbara M; Brady, Mark F; Harrell, Maria I et al. (2018) Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study. Clin Cancer Res 24:777-783
Crook, Juanita M; Zhang, Peixin; Pisansky, Thomas M et al. (2018) A Prospective Phase II Trial of Trans-perineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Cancer after External Beam Radiotherapy (NRG Oncology/RTOG -0526). Int J Radiat Oncol Biol Phys :
Cook, Elise D; Yeager, Katherine A; Cecchini, Reena S et al. (2018) Recruitment practices for U.S. minority and underserved populations in NRG oncology: Results of an online survey. Contemp Clin Trials Commun 10:100-104
Chan, John K; Brady, William; Monk, Bradley J et al. (2018) A phase II evaluation of sunitinib in the treatment of persistent or recurrent clear cell ovarian carcinoma: An NRG Oncology/Gynecologic Oncology Group Study (GOG-254). Gynecol Oncol 150:247-252

Showing the most recent 10 out of 331 publications