The Children's Oncology Group (COG) Statistics and Data Center (SDC), collaborates with the COG membership to design, conduct analyze and report the results of clinical trials of the treatment of childhood cancers and associated, laboratory-based, companion studies of the biology of these malignancies. Specifically, COG SDC personnel: Participate in the setting and evaluation of COG research priorities;collaborate in the development of study concepts and protocols. In particular, members of the SDC develop the study's statistical considerations;collaborate in the development and implementation of the study's case- report forms for the Group's clinical data management system;monitor study enrollment and the quality and completeness of study data submission;produce interim reports on study conduct and adverse event experience for the Group membership and protocol-specified interim analyses of study outcomes for the Group's Data and Safety Monitoring Committees;produce final reports of the study results for the Group membership;collaborate with laboratories to link specimen data and high dimensional genomics data with COG clinical and outcome data and to produce analyses of these data for publication;produce Technical Reports, detailing analyses performed for Group abstracts and manuscripts;conduct database and methodological research of relevance to the Group's research;perform CDUS and results reporting;monitor the performance of COG member institutions, producing reports for the Group's Institutional Performance monitoring Committee;provide data derived from COG studies to investigators external to the SDC in accordance with the policies and procedures of the Group;participate in National Clinical Trials Network initiatives and CTEP committees as appropriate.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10CA180899-01
Application #
8605640
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Mooney, Margaret M
Project Start
2014-04-15
Project End
2019-02-28
Budget Start
2014-04-15
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Florida
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Bagatell, Rochelle; McHugh, Kieran; Naranjo, Arlene et al. (2016) Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study. J Clin Oncol 34:740-6
Eidenschink Brodersen, L; Alonzo, T A; Menssen, A J et al. (2016) A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children's Oncology Group. Leukemia 30:2077-2080
Vora, Ajay; Andreano, Anita; Pui, Ching-Hon et al. (2016) Influence of Cranial Radiotherapy on Outcome in Children With Acute Lymphoblastic Leukemia Treated With Contemporary Therapy. J Clin Oncol 34:919-26
Kunin-Batson, Alicia S; Lu, Xiaomin; Balsamo, Lyn et al. (2016) Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study. Cancer 122:1608-17
Isakoff, Michael S; Goldsby, Robert; Villaluna, Doojduen et al. (2016) Rapid Protocol Enrollment in Osteosarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer 63:370-1
Miller, Tamara P; Li, Yimei; Kavcic, Marko et al. (2016) Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia. J Clin Oncol 34:1537-43
Jakacki, Regina I; Cohen, Kenneth J; Buxton, Allen et al. (2016) Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study. Neuro Oncol 18:1442-50
Marina, Neyssa M; Smeland, Sigbjørn; Bielack, Stefan S et al. (2016) Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol 17:1396-1408
Farrar, Jason E; Schuback, Heather L; Ries, Rhonda E et al. (2016) Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse. Cancer Res 76:2197-205
Oshima, Koichi; Khiabanian, Hossein; da Silva-Almeida, Ana C et al. (2016) Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 113:11306-11311

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