The Children's Oncology Group (COG) Statistics and Data Center (SDC), collaborates with the COG membership to design, conduct analyze and report the results of clinical trials of the treatment of childhood cancers and associated, laboratory-based, companion studies of the biology of these malignancies. Specifically, COG SDC personnel: Participate in the setting and evaluation of COG research priorities;collaborate in the development of study concepts and protocols. In particular, members of the SDC develop the study's statistical considerations;collaborate in the development and implementation of the study's case- report forms for the Group's clinical data management system;monitor study enrollment and the quality and completeness of study data submission;produce interim reports on study conduct and adverse event experience for the Group membership and protocol-specified interim analyses of study outcomes for the Group's Data and Safety Monitoring Committees;produce final reports of the study results for the Group membership;collaborate with laboratories to link specimen data and high dimensional genomics data with COG clinical and outcome data and to produce analyses of these data for publication;produce Technical Reports, detailing analyses performed for Group abstracts and manuscripts;conduct database and methodological research of relevance to the Group's research;perform CDUS and results reporting;monitor the performance of COG member institutions, producing reports for the Group's Institutional Performance monitoring Committee;provide data derived from COG studies to investigators external to the SDC in accordance with the policies and procedures of the Group;participate in National Clinical Trials Network initiatives and CTEP committees as appropriate.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10CA180899-01
Application #
8605640
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Mooney, Margaret M
Project Start
2014-04-15
Project End
2019-02-28
Budget Start
2014-04-15
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Florida
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Brown, Fiona C; Cifani, Paolo; Drill, Esther et al. (2017) Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia. Br J Haematol 176:86-91
Yanik, Gregory A; Parisi, Marguerite T; Naranjo, Arlene et al. (2017) Validation of post-induction Curie scores in high risk neuroblastoma. A Children's Oncology Group (COG) and SIOPEN group report on SIOPEN/HR-NBL1. J Nucl Med :
Wood, Brent; Wu, David; Crossley, Beryl et al. (2017) Measurable residual disease detection by high throughput sequencing improves risk stratification for pediatric B-ALL. Blood :
Applebaum, Mark A; Vaksman, Zalman; Lee, Sang Mee et al. (2017) Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project. Eur J Cancer 72:177-185
Rau, Rachel E; Dreyer, ZoAnn; Choi, Mi Rim et al. (2017) Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. Pediatr Blood Cancer :
Voigt, Andrew P; Brodersen, Lisa Eidenschink; Alonzo, Todd A et al. (2017) Phenotype in combination with genotype improves outcome prediction in acute myeloid leukemia: a report from Children's Oncology Group protocol AAML0531. Haematologica 102:2058-2068
Schwartz, Cindy L; Chen, Lu; McCarten, Kathleen et al. (2017) Childhood Hodgkin International Prognostic Score (CHIPS) Predicts event-free survival in Hodgkin Lymphoma: A Report from the Children's Oncology Group. Pediatr Blood Cancer 64:
Ferrari, Andrea; Chi, Yueh-Yun; De Salvo, Gian Luca et al. (2017) Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group. Eur J Cancer 78:1-6
Lee, Sanghoon; Day, Nancy S; Miles, Rodney R et al. (2017) Comparative genomic expression signatures of signal transduction pathways and targets in paediatric Burkitt lymphoma: a Children's Oncology Group report. Br J Haematol 177:601-611
Sandberg, Jesse K; Mullen, Elizabeth A; Cajaiba, Mariana M et al. (2017) Imaging of renal medullary carcinoma in children and young adults: a report from the Children's Oncology Group. Pediatr Radiol 47:1615-1621

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