This is a competing renewal application by the Appalachian Tri-State (ATS) Node of NIDA's Clinical Trials Network (CTN) in response to RFA-DA-10-009. During the previous funding period, the ATS Node made substantial contributions to CTN research, dissemination and administrative activities. We collaborated effectively with NIDA, other Nodes and community treatment providers (CTPs) in advancing the mission of the CTN by: 1) participating in four clinical trials and preparing for a fifth;2) contributing to new protocols under review;3) writing a treatment manual for a trial;4) developing and delivering clinical training protocols and fidelity scales for experimental interventions;5) disseminating information about NIDA Evidenced-Based Treatments (EBTs) through lectures, training programs, conferences, writings for professionals and writings for patients with drug problems;and 6) participating in CTN committees, work groups and national and regional dissemination conference planning committees. Four new CTN trials were implemented during the past 4 years and ATS was one of three CTN Nodes that participated in all four, having excellent subject recruitment for three of four CTN studies by exceeding our original recruitment goals by randomizing 255 subjects in these trials. In response to the changing research needs of NIDA to conduct clinical trials in non-addiction treatment settings, the ATS node expanded our CTPs to include medical and psychiatric systems and an HIV primary care clinic. To demonstrate our ability to contribute conceptually to future CTN projects, we propose a research agenda that focuses on studies of substance use disorders (SUDs) that co-occur with psychiatric and/or medical conditions. Studies of co-occurring medical and mental health conditions are needed because of the high prevalence of SUDs among those who have other illnesses and the lack of studies for many specialized clinical populations, especially patients in medical settings. Potential CTN studies could focus on screening, identifying and engaging patients with SUDs in these non-addiction settings as well as examining dissemination and cost-effectiveness of the interventions.
The funded application will improve the quality of drug abuse treatment throughout the country by conducting studies of behavioral, pharmacological, and integrated treatment interventions in rigorous, multi-site clinical trials to determine effectiveness across a broad range of treatment settings and diversified patient populations;and to ensuring the transfer of research results to physicians, clinicians, providers, and patients.
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|Sanjuan, Pilar M; Rice, Samara L; Witkiewitz, Katie et al. (2014) Alcohol, tobacco, and drug use among emergency department patients. Drug Alcohol Depend 138:32-8|
|Macias Konstantopoulos, Wendy L; Dreifuss, Jessica A; McDermott, Katherine A et al. (2014) Identifying patients with problematic drug use in the emergency department: results of a multisite study. Ann Emerg Med 64:516-25|
|Bogenschutz, Michael P; Donovan, Dennis M; Mandler, Raul N et al. (2014) Brief intervention for patients with problematic drug use presenting in emergency departments: a randomized clinical trial. JAMA Intern Med 174:1736-45|
|Winhusen, Theresa M; Brigham, Gregory S; Kropp, Frankie et al. (2014) A randomized trial of concurrent smoking-cessation and substance use disorder treatment in stimulant-dependent smokers. J Clin Psychiatry 75:336-43|
|Kelly, Thomas M; Daley, Dennis C; Douaihy, Antoine B (2014) Contingency management for patients with dual disorders in intensive outpatient treatment for addiction. J Dual Diagn 10:108-17|
|Wells, Elizabeth A; Donovan, Dennis M; Daley, Dennis C et al. (2014) Is level of exposure to a 12-step facilitation therapy associated with treatment outcome? J Subst Abuse Treat 47:265-74|
|Winhusen, Theresa M; Kropp, Frankie; Theobald, Jeff et al. (2014) Achieving smoking abstinence is associated with decreased cocaine use in cocaine-dependent patients receiving smoking-cessation treatment. Drug Alcohol Depend 134:391-5|
|Schackman, Bruce R; Metsch, Lisa R; Colfax, Grant N et al. (2013) The cost-effectiveness of rapid HIV testing in substance abuse treatment: results of a randomized trial. Drug Alcohol Depend 128:90-7|
|Daley, Dennis C; Feit, Marvin D (2013) The many roles of social workers in the prevention and treatment of alcohol and drug addiction: a major health and social problem affecting individuals, families, and society. Introduction. Soc Work Public Health 28:159-64|
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