This is a competing renewal application by the Appalachian Tri-State (ATS) Node of NIDA's Clinical Trials Network (CTN) in response to RFA-DA-10-009. During the previous funding period, the ATS Node made substantial contributions to CTN research, dissemination and administrative activities. We collaborated effectively with NIDA, other Nodes and community treatment providers (CTPs) in advancing the mission of the CTN by: 1) participating in four clinical trials and preparing for a fifth;2) contributing to new protocols under review;3) writing a treatment manual for a trial;4) developing and delivering clinical training protocols and fidelity scales for experimental interventions;5) disseminating information about NIDA Evidenced-Based Treatments (EBTs) through lectures, training programs, conferences, writings for professionals and writings for patients with drug problems;and 6) participating in CTN committees, work groups and national and regional dissemination conference planning committees. Four new CTN trials were implemented during the past 4 years and ATS was one of three CTN Nodes that participated in all four, having excellent subject recruitment for three of four CTN studies by exceeding our original recruitment goals by randomizing 255 subjects in these trials. In response to the changing research needs of NIDA to conduct clinical trials in non-addiction treatment settings, the ATS node expanded our CTPs to include medical and psychiatric systems and an HIV primary care clinic. To demonstrate our ability to contribute conceptually to future CTN projects, we propose a research agenda that focuses on studies of substance use disorders (SUDs) that co-occur with psychiatric and/or medical conditions. Studies of co-occurring medical and mental health conditions are needed because of the high prevalence of SUDs among those who have other illnesses and the lack of studies for many specialized clinical populations, especially patients in medical settings. Potential CTN studies could focus on screening, identifying and engaging patients with SUDs in these non-addiction settings as well as examining dissemination and cost-effectiveness of the interventions.
The funded application will improve the quality of drug abuse treatment throughout the country by conducting studies of behavioral, pharmacological, and integrated treatment interventions in rigorous, multi-site clinical trials to determine effectiveness across a broad range of treatment settings and diversified patient populations;and to ensuring the transfer of research results to physicians, clinicians, providers, and patients.
|Winhusen, Theresa; Feaster, Daniel J; Duan, Rui et al. (2017) Baseline Cigarette Smoking Status as a Predictor of Virologic Suppression and CD4 Cell Count During One-Year Follow-Up in Substance Users with Uncontrolled HIV Infection. AIDS Behav :|
|Pan, Yue; Liu, Hongmei; Metsch, Lisa R et al. (2017) Factors Associated with HIV Testing Among Participants from Substance Use Disorder Treatment Programs in the US: A Machine Learning Approach. AIDS Behav 21:534-546|
|Worley, Matthew J; Heinzerling, Keith G; Shoptaw, Steven et al. (2017) Volatility and change in chronic pain severity predict outcomes of treatment for prescription opioid addiction. Addiction 112:1202-1209|
|Magee, Joshua C; Winhusen, Theresa (2016) The coupling of nicotine and stimulant craving during treatment for stimulant dependence. J Consult Clin Psychol 84:230-7|
|Hernández, Diana; Feaster, Daniel J; Gooden, Lauren et al. (2016) Self-Reported HIV and HCV Screening Rates and Serostatus Among Substance Abuse Treatment Patients. AIDS Behav 20:204-14|
|Magee, Joshua C; Lewis, Daniel F; Winhusen, Theresa (2016) Evaluating Nicotine Craving, Withdrawal, and Substance Use as Mediators of Smoking Cessation in Cocaine- and Methamphetamine-Dependent Patients. Nicotine Tob Res 18:1196-201|
|Hatch-Maillette, Mary; Wells, Elizabeth A; Doyle, Suzanne R et al. (2016) Predictors of 12-Step Attendance and Participation for Individuals With Stimulant Use Disorders. J Subst Abuse Treat 68:74-82|
|Metsch, Lisa R; Feaster, Daniel J; Gooden, Lauren et al. (2016) Effect of Patient Navigation With or Without Financial Incentives on Viral Suppression Among Hospitalized Patients With HIV Infection and Substance Use: A Randomized Clinical Trial. JAMA 316:156-70|
|Gooden, Lauren; Metsch, Lisa R; Pereyra, Margaret R et al. (2016) Examining the Efficacy of HIV Risk-Reduction Counseling on the Sexual Risk Behaviors of a National Sample of Drug Abuse Treatment Clients: Analysis of Subgroups. AIDS Behav 20:1893-906|
|Worley, Matthew J; Shoptaw, Steven J; Bickel, Warren K et al. (2015) Using behavioral economics to predict opioid use during prescription opioid dependence treatment. Drug Alcohol Depend 148:62-8|
Showing the most recent 10 out of 47 publications