Prenatal substance exposure continues to be a major public health problem that affects millions of children and imposes enormous financial and social burdens on society. Little is known about the effects of prenatal cocaine exposure on the psychological, developmental, medical or physical outcomes in children entering adolescence. The Maternal Lifestyle Study (MLS) is an interagency collaboration involving the National Institute of Child Health and Human Development and the National Institute on Drug Abuse. MLS is being conducted in four academic centers: The University of Miami, University of Tennessee at Memphis, Wayne State University and Brown University. MLS is the largest clinical prospective longitudinal study to date of prenatal drug exposure and child outcome. The follow-up cohort includes 658 exposed and 730 non- exposed comparison children who have been studied through 9 years of age with 76% retention. The MLS study involves a unique population given its multi-site component, racial diversity, and extensive long-term follow up.
One aim i s to determine if prenatal cocaine or other prenatal drug exposure results in adverse psychological and neurodevelopmental outcomes at 12-15 years. These outcomes include substance use (early substance use onset, smoking, alcohol consumption and substance abuse and addiction), academic and cognitive deficits (e.g. poor school performance), altered physiological reactivity, antisocial behavior (eg. delinquency), psychopathology and risk taking behaviors, (e.g. adolescent pregnancy, sexually transmitted diseases). The role of protective factors such as positive parenting and peer relationships will also be investigated.
A second aim i s to determine the effects of prenatal cocaine exposure on physical and medical outcomes at 12-15 years. These outcomes include physical growth and medical illness, including hypertension, obesity, and metabolic disorders which may have their organs in fetal life, and be related to the impact of drug exposure on fetal growth. Additional outcomes include structural teratogenic effects (dysmorphology) and neurological disorders. In addition to being a study of prenatal cocaine exposure, MLS is also a study of children growing up in adverse conditions, providing information on development in typically developing children and children at risk. A thorough understanding of the consequences of prenatal cocaine exposure and associated maternal lifestyles is necessary for the development of treatment and public policy initiatives

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10DA024118-04
Application #
7800368
Study Section
Special Emphasis Panel (ZHD1-DSR-H (05))
Program Officer
Borek, Nicolette T
Project Start
2007-09-30
Project End
2011-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
4
Fiscal Year
2010
Total Cost
$564,803
Indirect Cost
Name
University of Miami School of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Locke, Robin L; Lagasse, Linda L; Seifer, Ronald et al. (2016) Effects of prenatal substance exposure on infant temperament vary by context. Dev Psychopathol 28:309-26
Salley, Brenda; Sheinkopf, Stephen J; Neal-Beevers, A Rebecca et al. (2016) Infants' early visual attention and social engagement as developmental precursors to joint attention. Dev Psychol 52:1721-1731
Conradt, Elisabeth; Beauchaine, Theodore; Abar, Beau et al. (2016) Early caregiving stress exposure moderates the relation between respiratory sinus arrhythmia reactivity at 1 month and biobehavioral outcomes at age 3. Psychophysiology 53:83-96
Lagasse, Linda L; Conradt, Elisabeth; Karalunas, Sarah L et al. (2016) Transactional relations between caregiving stress, executive functioning, and problem behavior from early childhood to early adolescence. Dev Psychopathol 28:743-56
Conradt, Elisabeth; Abar, Beau; Sheinkopf, Stephen et al. (2014) The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age. Dev Psychobiol 56:821-35
Conradt, Elisabeth; Lagasse, Linda L; Shankaran, Seetha et al. (2014) Physiological correlates of neurobehavioral disinhibition that relate to drug use and risky sexual behavior in adolescents with prenatal substance exposure. Dev Neurosci 36:306-15
Conradt, Elisabeth; Abar, Beau; Lester, Barry M et al. (2014) Cortisol reactivity to social stress as a mediator of early adversity on risk and adaptive outcomes. Child Dev 85:2279-98
Conradt, Elisabeth; Degarmo, David; Fisher, Phil et al. (2014) The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure. Dev Psychopathol 26:901-16
Lambert, Brittany L; Bann, Carla M; Bauer, Charles R et al. (2013) Risk-taking behavior among adolescents with prenatal drug exposure and extrauterine environmental adversity. J Dev Behav Pediatr 34:669-79
Conradt, Elisabeth; Sheinkopf, Stephen J; Lester, Barry M et al. (2013) Prenatal substance exposure: neurobiologic organization at 1 month. J Pediatr 163:989-94.e1

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