HHS/CDC/NCBDDD and the Danish Agency for Science, Technology and Innovation initiated a cooperative agreement to develop and implement a US-Denmark collaborative laboratory and epidemiologic infrastructure - with emphasis on activities drawing on the unique research resources in Denmark (national registries, biobanks and the Danish National Birth Cohort [DNBC]). The focus of this application for the HHS-Denmark program, will build upon the core features of the existing program to carry out current activities and serve as a foundation for potential new or expanded topics. All proposed activities will include one or more of the following core features: 1) enhancement of existing registries and biobanks, 2) registry-based analytic epidemiologic studies; 3) DNBC-based analytic epidemiologic studies, including participant-follow-up; and 4) laboratory methods development and application on existing biologic samples. Specifically, we propose to conduct: 1) Registry-based analytic epidemiologic studies including: a. secular trends analyses of autism; b. association between cerebral palsy and coagulation abnormalities; c. association between autism and cerebral palsy and artificial reproductive techniques. 2) DNBC-based analytic epidemiologic studies of: a. childhood developmental effects of lifestyle behaviors in pregnancy; b. prenatal biomarkers and risk factors for autism and cerebral palsy. 3) Laboratory studies of biomarkers of risk and clinical perinatal risk factors for autism and cerebral palsy, with a focus on analyses of biomarkers of infection, inflammation, coagulation abnormalities and brain development. 4) Maintain and enhance the collaborative epidemiologic and laboratory infrastructure: a. Maintain the National Cerebral Palsy Registry; b. Finalize the pilot validation study of autism diagnoses from the Danish Psychiatric Central Register; c. Develop assays for biomarker studies of ASD and CP. Further, we believe we have established a sound infrastructure as the basis for future activities that may arise between HHS and the Danish Agency for Science, Technology and Innovation.

Agency
National Institute of Health (NIH)
Institute
Centers for Disease Control and Prevention (NCBDD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10DD000230-02S1
Application #
7680459
Study Section
Special Emphasis Panel (ZCD1-CJM (01))
Program Officer
Irannejad, Nassi
Project Start
2007-05-01
Project End
2012-01-31
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
2
Fiscal Year
2008
Total Cost
$111,511
Indirect Cost
Name
Danish Agency/Science, Tech & Innovation
Department
Type
DUNS #
305225679
City
Copenhagen
State
Country
Denmark
Zip Code
1260
Zhu, Jin Liang; Obel, Carsten; Hasle, Henrik et al. (2014) Social conditions for people with Down syndrome: a register-based cohort study in Denmark. Am J Med Genet A 164A:36-41
Zhu, Jin Liang; Hasle, Henrik; Correa, Adolfo et al. (2013) Hospitalizations among people with Down syndrome: a nationwide population-based study in Denmark. Am J Med Genet A 161A:650-7
Zhu, Jin Liang; Hasle, Henrik; Correa, Adolfo et al. (2013) Survival among people with Down syndrome: a nationwide population-based study in Denmark. Genet Med 15:64-9