This proposal is for the University of Houston, College of Optometry (UHCO) to serve as one of four clinical centers in the Correction of Myopia Evaluation Trial (COMET). COMET is a prospective, randomized clinical trial designed to assess whether progressive addition lenses (PAL's) slow the progression of juvenile-onset myopia, compared to conventional single vision lenses (SV). A total of four hundred children, 6-12 years of age with myopia (-1.25 to -4.50 D) in both eyes, who meet specific inclusion and exclusion criteria will be enrolled in the 4 participating centers. One hundred twelve children will be identified in Houston. These children will be recruited primarily from the University Eye Institute (UEI - the Clinic at UHCO). All eligible children will be examined at baseline and at six-month intervals for at least three years to measure changes in refractive error and to update prescriptions. A standardized, common protocol will be used at all four centers. The primary outcome measure is progression of myopia, as measured by cycloplegic autorefraction. A additional outcome measure is axial elongation as measured by A-scan ultrasonography. These outcome measures will be obtained by masked examiners. This application documents the ability of UHCO to recruit at least 112 children within one academic year, and to retain them for at least three years. Documentation is also provided that UHCO has the personnel, equipment, and facilities to conduct the study in accordance with the COMET Manual of Procedures (MOP). Complete details of the COMET rationale, design, and methods are contained in the MOP, which is submitted separately with the Study Chair and Coordinating Center applications. In addition to UHCO, the other clinical centers are located at Colleges of Optometry in Boston, Birmingham, and Philadelphia, with the Study Chair in Boston and the Coordinating Center at Stony Brook NY.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY011740-04
Application #
6164696
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Everett, Donald F
Project Start
1997-03-01
Project End
2002-02-28
Budget Start
2000-03-01
Budget End
2001-02-28
Support Year
4
Fiscal Year
2000
Total Cost
$153,079
Indirect Cost
Name
University of Houston
Department
Other Health Professions
Type
Schools of Optometry/Ophthalmol
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77204
Hou, Wei; Norton, Thomas T; Hyman, Leslie et al. (2018) Axial Elongation in Myopic Children and its Association With Myopia Progression in the Correction of Myopia Evaluation Trial. Eye Contact Lens 44:248-259
Scheiman, Mitchell; Gwiazda, Jane; Zhang, Qinghua et al. (2016) Longitudinal changes in corneal curvature and its relationship to axial length in the Correction of Myopia Evaluation Trial (COMET) cohort. J Optom 9:13-21
Gwiazda, Jane; Norton, Thomas T; Hou, Wei et al. (2016) Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET). Curr Eye Res 41:492-500
Manny, Ruth E; Deng, Li; Gwiazda, Jane et al. (2016) Internal Astigmatism in Myopes and Non-myopes: Compensation or Constant? Optom Vis Sci 93:1079-92
Liu, Lei; Marsh-Tootle, Wendy; Harb, Elise N et al. (2016) A sloped piecemeal Gaussian model for characterising foveal pit shape. Ophthalmic Physiol Opt 36:615-631
Harb, Elise; Hyman, Leslie; Gwiazda, Jane et al. (2015) Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort. Am J Ophthalmol 160:62-71.e2
Scheiman, Mitchell; Zhang, Qinghua; Gwiazda, Jane et al. (2014) Visual activity and its association with myopia stabilisation. Ophthalmic Physiol Opt 34:353-61
Gwiazda, Jane; Deng, Li; Manny, Ruth et al. (2014) Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci 55:752-8
Deng, Li; Gwiazda, Jane; Manny, Ruth E et al. (2014) Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the Correction of Myopia Evaluation Trial. Invest Ophthalmol Vis Sci 55:2097-105
Dias, Lynette; Manny, Ruth E; Weissberg, Erik et al. (2013) Myopia, contact lens use and self-esteem. Ophthalmic Physiol Opt 33:573-80

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