This proposal is for the Houston Clinical Center to continue to annually examine the 116 currently enrolled COSMICC participants (only 2 subjects have withdrawn since recruited in 97-98) at the Houston center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address specific aims described in more detail in the Chairman's grant and summarized briefly as :1)to use mathematical functions (the Gompers function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia);2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of mopes;and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health Problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY011740-15
Application #
8386600
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Everett, Donald F
Project Start
1997-03-01
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2014-11-30
Support Year
15
Fiscal Year
2013
Total Cost
$69,071
Indirect Cost
$83,959
Name
University of Houston
Department
None
Type
Schools of Optometry/Ophthalmol
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
Deng, Li; Gwiazda, Jane; Manny, Ruth E et al. (2014) Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the Correction of Myopia Evaluation Trial. Invest Ophthalmol Vis Sci 55:2097-105
Scheiman, Mitchell; Zhang, Qinghua; Gwiazda, Jane et al. (2014) Visual activity and its association with myopia stabilisation. Ophthalmic Physiol Opt 34:353-61
Gwiazda, Jane; Deng, Li; Manny, Ruth et al. (2014) Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci 55:752-8
Harb, Elise; Hyman, Leslie; Fazzari, Melissa et al. (2012) Factors associated with macular thickness in the COMET myopic cohort. Optom Vis Sci 89:620-31
Gwiazda, Jane; Deng, Li; Dias, Lynette et al. (2011) Association of education and occupation with myopia in COMET parents. Optom Vis Sci 88:1045-53
Anderson, Heather; Stuebing, Karla K; Fern, Karen D et al. (2011) Ten-year changes in fusional vergence, phoria, and nearpoint of convergence in myopic children. Optom Vis Sci 88:1060-5
Manny, Ruth E; Deng, Li; Crossnoe, Connie et al. (2008) IOP, myopic progression and axial length in a COMET subgroup. Optom Vis Sci 85:97-105
Gwiazda, Jane; Hyman, Leslie; Dong, Li Ming et al. (2007) Factors associated with high myopia after 7 years of follow-up in the Correction of Myopia Evaluation Trial (COMET) Cohort. Ophthalmic Epidemiol 14:230-7
Kurtz, Daniel; Hyman, Leslie; Gwiazda, Jane E et al. (2007) Role of parental myopia in the progression of myopia and its interaction with treatment in COMET children. Invest Ophthalmol Vis Sci 48:562-70
Dong, Li Ming; Hyman, Leslie; Manny, Ruth E et al. (2006) Evaluating masking in a randomized, double-masked clinical trial in children with myopia. Optom Vis Sci 83:46-52

Showing the most recent 10 out of 22 publications