The current proposal provides a unique opportunity to investigate the development of eye disease in a population-based study of the largest minority group in the United States and to examine novel lifestyle, biologic and genetic hypotheses related to the risk of developing these diseases. The study is designed to capture the 8-year incidence of the major vision-threatening eye diseases in Latinos (Mexican-Americans), including early age-related maculopathy (ARM), diabetic retinopathy (DR), and open-angle glaucoma (OAG), and the impact of these diseases on visual function. This application builds on the knowledge gained from the Los Angeles Latino Eye Study (LALES), a population-based study of 6,357 Mexican-Americans aged 40 years and older. The cohort was assembled by recruiting Latino adults residing in 6 census tracts in Los Angeles County with clinical eye examinations given in 2000-2003 and re-examinations in 2004-2008. The data obtained from this study have been used to document the prevalence, incidence, and impact of visual impairment, ARM, DR, and OAG over a 4-year period. In this application, we propose to re-examine the LALES cohort 8 years after the baseline examination. The additional incident cases that will be collected through 8 years of follow up will be needed for (i) biological and behavioral risk factor analyses, including time-dependent covariates assessed at baseline and follow-up (ii) replication of findings from cross-sectional (prevalent) analyses using incident data while avoiding issues of temporality that can be of concern when exposure history or quality of life data is collected after disease is diagnosed and (iii) genetic analyses for a genome-wide association study (GWAS) of DR and early ARM.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10EY011753-11A1
Application #
7763408
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Program Officer
Kurinij, Natalie
Project Start
1998-09-30
Project End
2014-09-29
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
11
Fiscal Year
2010
Total Cost
$2,459,091
Indirect Cost
Name
University of Southern California
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Nannini, Drew; Torres, Mina; Chen, Yii-Der I et al. (2016) Reply. Ophthalmology 123:e31-2
Nannini, Drew; Torres, Mina; Chen, Yii-Der I et al. (2016) African Ancestry Is Associated with Higher Intraocular Pressure in Latinos. Ophthalmology 123:102-8
Palmer, Nicholette D; Goodarzi, Mark O; Langefeld, Carl D et al. (2015) Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes 64:1853-66
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Kempen, John H; Sugar, Elizabeth A; Varma, Rohit et al. (2014) Risk of cataract among subjects with acquired immune deficiency syndrome free of ocular opportunistic infections. Ophthalmology 121:2317-24
Gao, Xiaoyi; Gauderman, W James; Liu, Yutao et al. (2013) A genome-wide association study of central corneal thickness in Latinos. Invest Ophthalmol Vis Sci 54:2435-43
Varma, Rohit; McKean-Cowdin, Roberta; Vitale, Susan et al. (2013) Vision assessment using the NIH Toolbox. Neurology 80:S37-40

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