The Correction of Myopia Evaluation Trial (COMET) is a multi-center, randomized, double-masked clinical trial designed to assess whether progressive addition lenses (PAL's) slow the progression of juvenile-onset myopia, as compared to conventional single vision lenses (SV). Four participating clinical centers, at Colleges of Optometry in Boston, Birmingham, Philadelphia, and Houston, will enroll a study total of 450 children with myopia (-1.25 D to -4.5 D) in both eyes, 6-12 years old, who meet specific inclusion and exclusion criteria. They will be identified primarily from elementary school vision screenings and College of Optometry clinical patient records. All eligible children will be examined at baseline and at six-month intervals for at least three years to measure changes in refractive error and to update prescriptions. A standardized, common protocol will be used at all centers. The primary outcome measure is progression of myopia, as measured by cycloplegic autorefraction. An additional outcome measure is axial elongation as measured by A-scan ultrasonography. These will be obtained by masked examiners. In addition to presenting the COMET study in general, this application seeks support for the Study Chair's Office at the New England College of Optometry. Complete details of the COMET rationale, design, and methods are contained in the attached Manual of Procedures. Resource centers for the COMET are the Study Chair's Office in Boston, MA, and the Coordinating Center in Stony Brook, NY.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY011756-04
Application #
2888563
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Project Start
1997-02-07
Project End
2001-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
New England College of Optometry
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
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Scheiman, Mitchell; Gwiazda, Jane; Zhang, Qinghua et al. (2016) Longitudinal changes in corneal curvature and its relationship to axial length in the Correction of Myopia Evaluation Trial (COMET) cohort. J Optom 9:13-21
Gwiazda, Jane; Norton, Thomas T; Hou, Wei et al. (2016) Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET). Curr Eye Res 41:492-500
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Harb, Elise; Hyman, Leslie; Gwiazda, Jane et al. (2015) Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort. Am J Ophthalmol 160:62-71.e2
Scheiman, Mitchell; Zhang, Qinghua; Gwiazda, Jane et al. (2014) Visual activity and its association with myopia stabilisation. Ophthalmic Physiol Opt 34:353-61
Gwiazda, Jane; Deng, Li; Manny, Ruth et al. (2014) Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci 55:752-8
Deng, Li; Gwiazda, Jane; Manny, Ruth E et al. (2014) Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the Correction of Myopia Evaluation Trial. Invest Ophthalmol Vis Sci 55:2097-105
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