Program Director/Principal Investigator (Last, First, Middle): Harvey, Erin M PROJECT SUIVIMARY (See instructions): The visual experience of the uncorrected astigmat provides a unique natural experiment on the effect of chronic blur on visual development. Studies of Tohono O'odham children, 30 to 40% of whom have visually significant astigmatism, provide a unique opportunity for investigation ofthe effects of astigmatism.
The first aim i s to study the stability of astigmatism in Tohono O'odham children over time, and to determine the anatomical origins of their astigmatism. Measurements of the posterior cornea will provide fundamental data on the origin of the internal astigmatism that often compensates for external (anterior) corneal astigmatism.
The second aim i s to determine how astigmats perform in the everyday complex visual environment. Specifically, we will examine the relation between astigmatic refractive error and (a) compliance with spectacle correction, (b) accommodation patterns, and (c) performance of complex perceptual tasks. By examining the influence of social, refractive, visual performance, and accommodation factors on compliance, we will provide a uniquely broad analysis of barriers to compliance, will provide essential information for development of strategies to increase treatment compliance in this population, and may identify barriers to compliance that are relevant to astigmats in general. Measures of accommodation under various task demand conditions will allow us to better understand how astigmats compensate for the unique persistent blur introduced by astigmatism, and will allow us to better understand how these strategies impact visual development. Finally, data on how astigmatism influences performance on tasks that require visual motor integration, reading fluency, and global perception of form and motion will provide valuable insight into how astigmatism impacts everyday functioning. In summary, access to this unique population of high astigmats introduces a valuable opportunity to conduct novel studies to further our understanding of the long-term stability and anatomic origins of astigmatism and to explore the effects of astigmatism on functioning in a complex visual environment.

Public Health Relevance

This research will provide the first analysis of the anatomic origins of astigmatism in this population, generate important clinical information for development of guidelines for treatment and prevention of astigmatism-related amblyopia, and will further our understanding of the influence of astigmatism on visual functioning. Results will benefit astigmatic Tohono O'odham children and astigmatic children in general.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY013153-13
Application #
8312492
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Everett, Donald F
Project Start
2000-09-15
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
13
Fiscal Year
2012
Total Cost
$827,950
Indirect Cost
$170,847
Name
University of Arizona
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Crescioni, Mabel; Messer, Dawn H; Warholak, Terri L et al. (2014) Rasch analysis of the Student Refractive Error and Eyeglass Questionnaire. Optom Vis Sci 91:624-33
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim et al. (2013) Developmental changes in anterior corneal astigmatism in Tohono O'odham Native American infants and children. Ophthalmic Epidemiol 20:102-8
Twelker, J Daniel; Miller, Joseph M; Sherrill, Duane L et al. (2013) Astigmatism and myopia in Tohono O'odham Native American children. Optom Vis Sci 90:1267-73
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim (2013) Utility of an open field Shack-Hartmann aberrometer for measurement of refractive error in infants and young children. J AAPOS 17:494-500
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim et al. (2011) Accuracy and validity of IK4 handheld video keratometer measurements in children. J AAPOS 15:407-9
Harvey, Erin M; Dobson, Velma; Miller, Joseph M et al. (2011) Prevalence of corneal astigmatism in Tohono O'odham Native American children 6 months to 8 years of age. Invest Ophthalmol Vis Sci 52:4350-5
Harvey, Erin M; Dobson, Velma; Miller, Joseph M et al. (2009) Accuracy of the Welch Allyn SureSight for measurement of magnitude of astigmatism in 3- to 7-year-old children. J AAPOS 13:466-71
Dobson, Velma; Clifford-Donaldson, Candice E; Miller, Joseph M et al. (2009) A comparison of Lea Symbol vs ETDRS letter distance visual acuity in a population of young children with a high prevalence of astigmatism. J AAPOS 13:253-7
Miller, Joseph M (2009) Clinical applications of power vectors. Optom Vis Sci 86:599-602
Harvey, Erin M (2009) Development and treatment of astigmatism-related amblyopia. Optom Vis Sci 86:634-9

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