This application is for a five-year extension of funding for the Diabetic Retinopathy Clinical Research Network ( Coordinating Center. The objective of the is to develop and maintain a collaborative network to facilitate multicenter clinical research on diabetic retinopathy, diabetic macular edema and associated conditions, leading and growing causes of vision impairment and blindness in the United States and throughout the world. Its priorities include involvement of community-based practices as well as university-based centers and to collaborate with industry to facilitate investigations and opportunities otherwise not possible, but to do so in a manner consistent with the Network's dedication to academic integrity and optimal clinical trial performance. The Coordinating Center plays a key role in the Network's ability to achieve its goals. During the next funding cycle, the network proposes to complete 5 protocols that are expected to be in progress at the time the funding period begins, initiate approximately 10 new protocols (approximately 1 new major protocol and 1 new minor protocol per year) in diabetic retinopathy, diabetic macular edema and associated conditions, develop and implement new methods for electronic data capture of retinal images to facilitate the conduct of diabetic retinopathy clinical trials, continue to expand the by soliciting the participation of new sites and encouraging the involvement of investigators who recently have completed fellowship training (see Operations Center proposal), continue to educate the investigators on the principles of clinical research, and mentor selected retina specialists to be leaders in clinical trials with specific reference to diabetic retinopathy and associated diseases.

National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZEY1-VSN (03))
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Schron, Eleanor
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Jaeb Center for Health Research, Inc.
United States
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Jampol, Lee M; Bressler, Neil M; Glassman, Adam R (2014) Revolution to a new standard treatment of diabetic macular edema. JAMA 311:2269-70
Diabetic Retinopathy Clinical Research Network Writing Committee; Bressler, Susan B; Edwards, Allison R et al. (2014) Reproducibility of spectral-domain optical coherence tomography retinal thickness measurements and conversion to equivalent time-domain metrics in diabetic macular edema. JAMA Ophthalmol 132:1113-22
Diabetic Retinopathy Clinical Research Network Authors/Writing Committee; Bressler, Susan B; Baker, Carl W et al. (2014) Pilot study of individuals with diabetic macular edema undergoing cataract surgery. JAMA Ophthalmol 132:224-6
Bressler, Susan B; Almukhtar, Talat; Aiello, Lloyd P et al. (2013) Green or yellow laser treatment for diabetic macular edema: exploratory assessment within the Diabetic Retinopathy Clinical Research Network. Retina 33:2080-8
Diabetic Retinopathy Clinical Research Network Authors/Writing Committee; Baker, Carl W; Almukhtar, Talat et al. (2013) Macular edema after cataract surgery in eyes without preoperative central-involved diabetic macular edema. JAMA Ophthalmol 131:870-9
Diabetic Retinopathy Clinical Research Network* (2013) Randomized clinical trial evaluating intravitreal ranibizumab or saline for vitreous hemorrhage from proliferative diabetic retinopathy. JAMA Ophthalmol 131:283-93
Bressler, Susan B; Qin, Haijing; Melia, Michele et al. (2013) Exploratory analysis of the effect of intravitreal ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial. JAMA Ophthalmol 131:1033-40
Glassman, Adam R; Stockdale, Cynthia R; Beck, Roy W et al. (2012) Evaluation of masking study participants to intravitreal injections in a randomized clinical trial. Arch Ophthalmol 130:190-4
Sun, Jennifer K; Qin, Haijing; Aiello, Lloyd Paul et al. (2012) Evaluation of visual acuity measurements after autorefraction vs manual refraction in eyes with and without diabetic macular edema. Arch Ophthalmol 130:470-9
Elman, Michael J; Bressler, Neil M; Qin, Haijing et al. (2011) Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 118:609-14

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