The University of Wisconsin Fundus Photograph Reading Center (UW FPRC) proposes to serve as photograph reading center for the Intravitreal Corticosteroid for Macular Edema study. To accomplish this, we propose to: 1. Apply current procedures for documenting and grading macular edema. We can provide protocols for macular edema imaging (color stereoscopic fundus photographs, fluorescein angiograms, and optical coherence tomograms), and are experienced at orienting, certifying, and giving feedback to clinic photographers. By extending the Early Treatment Diabetic Retinopathy Study classification, we have protocols for evaluation/grading of macular edema from color photographs and fluorescein angiograms. We are developing a protocol for assessment of QCT scans. 2. Assist the study chair and study investigators in 1) the conduct of the clinical trial (for example, timely review of photographs and angiograms for eligibility), 2) the analysis of the resultant data and 3) the preparation of manuscripts for publication. The UW FPRC principal investigator and staff are experienced at participation in collaborative multi-center clinical trials and are strongly committed to the study of new treatments for macular edema due to diabetes mellitus and retinal vein occlusion. PERFORMANCESITE(S)(organization,city,state) University of Wisconsin Department of Ophthalmology and Visual Sciences Fundus Photograph Reading Center 610 N.Walnut St., Room 438 Madison, WI 53705 KEY PERSONNEL. See instructions. Use continuation pages as neededto provide the required information in the format shown below. Starl with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Blodi, Barbara A. University of Wisconsin Principal Investigator Davis, Matthew D. University of Wisconsin Co-Investigator Disclosure Permission Statement. Applicableto SBIR/STTROnly.See instructions. Yes No PHS 398 (Rev. 05/01) Page 2___ Form Page 2 __Number pag.......... tively at the bottom throughout the application Do not ..... ffi ...... has3a 3b. d- t ? Principal Investigator/Program Director (Last, first, middle). Blodi, Barbara A. The nameofthe principalinvestigator/programdirectormustbe providedat thetop of eachprintedpageand eachcontinuationpage Type density and size must conform to limits and specifications provided in the PHS398 Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .............................................. 1 Description,

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10EY014352-04S1
Application #
7616915
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Redford, Maryann
Project Start
2003-06-01
Project End
2010-04-30
Budget Start
2007-05-01
Budget End
2010-04-30
Support Year
4
Fiscal Year
2008
Total Cost
$331,906
Indirect Cost
Name
University of Wisconsin Madison
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Aref, Ahmad A; Scott, Ingrid U; Oden, Neal L et al. (2015) Incidence, Risk Factors, and Timing of Elevated Intraocular Pressure After Intravitreal Triamcinolone Acetonide Injection for Macular Edema Secondary to Retinal Vein Occlusion: SCORE Study Report 15. JAMA Ophthalmol 133:1022-9
Weinberg, David V; Wahle, Aimee E; Ip, Michael S et al. (2013) Score Study Report 12: Development of venous collaterals in the Score Study. Retina 33:287-95
Scott, Ingrid U; Vanveldhuisen, Paul C; Oden, Neal L et al. (2012) Baseline characteristics and response to treatment of participants with hemiretinal compared with branch retinal or central retinal vein occlusion in the standard care vs corticosteroid for retinal vein occlusion (SCORE) study: SCORE study report 14. Arch Ophthalmol 130:1517-24
Chan, Clement K; Ip, Michael S; Vanveldhuisen, Paul C et al. (2011) SCORE Study report #11: incidences of neovascular events in eyes with retinal vein occlusion. Ophthalmology 118:1364-72
Scott, Ingrid U; VanVeldhuisen, Paul C; Oden, Neal L et al. (2011) Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion: Standard Care Versus COrticosteroid for REtinal Vein Occlusion Study report 10. Ophthalmology 118:345-52
Oden, Neal; Vanveldhuisen, Paul C; Scott, Ingrid U et al. (2010) SCORE Study Report 8: Closed Tests for All Pair-Wise Comparisons of Means. Drug Inf J 44:405-420
Blodi, Barbara A; Domalpally, Amitha; Scott, Ingrid U et al. (2010) Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study system for evaluation of stereoscopic color fundus photographs and fluorescein angiograms: SCORE Study Report 9. Arch Ophthalmol 128:1140-5
Scott, Ingrid U; Oden, Neal L; VanVeldhuisen, Paul C et al. (2009) SCORE Study Report 7: incidence of intravitreal silicone oil droplets associated with staked-on vs luer cone syringe design. Am J Ophthalmol 148:725-732.e7
Scott, Ingrid U; Ip, Michael S; VanVeldhuisen, Paul C et al. (2009) A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlu Arch Ophthalmol 127:1115-28
Scott, Ingrid U; VanVeldhuisen, Paul C; Oden, Neal L et al. (2009) SCORE Study report 1: baseline associations between central retinal thickness and visual acuity in patients with retinal vein occlusion. Ophthalmology 116:504-12

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