The Neuro-Ophthalmology Research Disease Investigator Consortium (NORDIC) is an organization composed of neuro-ophthalmologists and other doctors, structured to perform prospective clinical research. Neuro-Ophthalmology is a subspecialty of Neurology and Ophthalmology that addresses scientific and medical aspects that bridge both specialties. There is a broad spectrum of Neuro-ophthalmologic disorders that collectively affect millions of people. Many of these are visual disorders associated with other systemic or neurological conditions and many fit the US Government definition as "rare" diseases and have not been adequately investigated. The Network is prepared to conduct studies on two of these disorders: idiopathic intracranial hypertension and thyroid eye disease. There is little consensus among practitioners on the diagnostic evaluation or therapy for many neuro-ophthalmological disorders. NORDIC will provide the organization and operational capability to perform multi-site observational and treatment trials, involving nearly 200 community and academic practitioners, in order to address the many crucial yet unanswered questions about risks, diagnosis, treatment and other management-aspects of these diseases that could not be studied without a clinical research organization. The NORDIC strategy is to provide a strong Central Coordination, to an open network of investigators at sites, in order to conduct multiple trials in parallel, employing protocols that can be incorporated into standard clinical practice. The strong central coordination is provided by: the NORDIC Chair and Executive Committee who are recognized leaders in neuroophthalmic and clinical research;the use of steering committees for each study;a Data Coordination and Biostatistics Center that is expert at national, multi-site studies;and reading centers appropriate for neuroophthalmic assessments. The open network and structure will allow practitioners to develop new studies, become certified and participate in specific studies and protocols, as appropriate to their expertise and interests. This approach will allow the recruitment and study of powerful numbers of otherwise-hard-to-find study patients, with a high degree of control over the scientific quality of the research projects. The products of the NORDIC strategy will be evidence-based diagnostic and treatment solutions that can be applied to enhance the visual health of a significant portion of the population.

National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZEY1-VSN (05))
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Schron, Eleanor
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St. Luke's-Roosevelt Institute for Health Sciences
New York
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Wall, Michael; Kupersmith, Mark J; Kieburtz, Karl D et al. (2014) The idiopathic intracranial hypertension treatment trial: clinical profile at baseline. JAMA Neurol 71:693-701
Sibony, Patrick; Strachovsky, Matthew; Honkanen, Robert et al. (2014) Optical coherence tomography shape analysis of the peripapillary retinal pigment epithelium layer in presumed optic nerve sheath meningiomas. J Neuroophthalmol 34:130-6
Chen, John; Wall, Michael (2014) Epidemiology and risk factors for idiopathic intracranial hypertension. Int Ophthalmol Clin 54:1-11
NORDIC Idiopathic Intracranial Hypertension Study Group Writing Committee; Wall, Michael; McDermott, Michael P et al. (2014) Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA 311:1641-51
Friedman, Deborah I; McDermott, Michael P; Kieburtz, Karl et al. (2014) The idiopathic intracranial hypertension treatment trial: design considerations and methods. J Neuroophthalmol 34:107-17
Thurtell, Matthew J; Wall, Michael (2013) Idiopathic intracranial hypertension (pseudotumor cerebri): recognition, treatment, and ongoing management. Curr Treat Options Neurol 15:1-12
Kupersmith, Mark J; Kardon, Randy; Durbin, Mary et al. (2012) Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT. Invest Ophthalmol Vis Sci 53:1962-70
Kupersmith, Mark J; Sibony, Patrick; Mandel, Gary et al. (2011) Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary retinal pigment epithelium layer in papilledema. Invest Ophthalmol Vis Sci 52:6558-64
Wall, Michael; Corbett, James J (2011) Cup-to-disc ratio in patients with idiopathic intracranial hypertension is smaller than in normal subjects? J Neuroophthalmol 31:95-6
Sibony, Patrick; Kupersmith, Mark J; Rohlf, F James (2011) Shape analysis of the peripapillary RPE layer in papilledema and ischemic optic neuropathy. Invest Ophthalmol Vis Sci 52:7987-95

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