The Comparison of AMD Treatments Trial (CATT) is a multi-center, randomized clinical trial investigating the treatment of neovascular AMD with Lucentis and Avastin. The primary objective of the activities proposed in this fundus Photograph Reading Center (FPRC) application is to provide support to the CATT. This support includes A) the evaluation of follow-up visit fundus photographs to assess the changes in the choroidal neovascularization and the changes in retinal vessel diameters following both treatments;and B) assessment of the correlation of these findings with the findings of the CATT OCT Reading Center. This continuation grant proposal has two Specific Aims:
Aim 1, to complete in all participants the two-year follow up of the original CATT grant application. Because enrolment of patients in the CATT trial was delayed, the period needed to complete the two year follow up must be extended beyond the time period proposed in the original plan.
Aim 2, to perform an observational study for an additional 3-year follow up to investigate the long term effects of the study medications. Throughout the proposed studies the FPRC will provide reliable, timely, reproducible, and systematic grading of submitted color photographs and angiographic image materials for CATT. These activities will be similar to those provided in the first years of the CATT study. The FPRC will also continue to implement study specific materials and methods for reader, photographer, clinic coordinator, and ophthalmologist certification and training. FPRC activities will also support study goals as an image resource for recruitment, Study Group meetings, presentations and publications.

Public Health Relevance

Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and most western countries. These studies of the relative effectiveness and safety of the two drugs under study will determine how patients with neovascular ("wet") AMD are treated in the future.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY017826-08
Application #
8415893
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Redford, Maryann
Project Start
2006-09-30
Project End
2014-08-31
Budget Start
2013-02-01
Budget End
2014-08-31
Support Year
8
Fiscal Year
2013
Total Cost
$33,217
Indirect Cost
$118,258
Name
University of Pennsylvania
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ying, Gui-shuang; Kim, Benjamin J; Maguire, Maureen G et al. (2014) Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials. JAMA Ophthalmol 132:915-21
Daniel, Ebenezer; Toth, Cynthia A; Grunwald, Juan E et al. (2014) Risk of scar in the comparison of age-related macular degeneration treatments trials. Ophthalmology 121:656-66
Grunwald, Juan E; Daniel, Ebenezer; Huang, Jiayan et al. (2014) Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials. Ophthalmology 121:150-61
Folgar, Francisco A; Jaffe, Glenn J; Ying, Gui-Shuang et al. (2014) Comparison of optical coherence tomography assessments in the comparison of age-related macular degeneration treatments trials. Ophthalmology 121:1956-65
Hagstrom, Stephanie A; Ying, Gui-shuang; Pauer, Gayle J T et al. (2014) VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: comparison of age-related macular degeneration treatments trials (CATT). JAMA Ophthalmol 132:521-7
Hagstrom, Stephanie A; Ying, Gui-Shuang; Pauer, Gayle J T et al. (2014) Endothelial PAS domain-containing protein 1 (EPAS1) gene polymorphisms and response to anti-VEGF therapy in the comparison of AMD treatments trials (CATT). Ophthalmology 121:1663-4.e1
Kim, Benjamin J; Ying, Gui-Shuang; Huang, Jiayan et al. (2014) Sporadic visual acuity loss in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Am J Ophthalmol 158:128-135.e10
Gewaily, Dina Y; Grunwald, Juan E; Pistilli, Maxwell et al. (2014) Delayed patchy choroidal filling in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Am J Ophthalmol 158:525-31.e2
Hagstrom, Stephanie A; Ying, Gui-Shuang; Pauer, Gayle J T et al. (2013) Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT). Ophthalmology 120:593-9
Jaffe, Glenn J; Martin, Daniel F; Toth, Cynthia A et al. (2013) Macular morphology and visual acuity in the comparison of age-related macular degeneration treatments trials. Ophthalmology 120:1860-70

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