The objective of the Diabetic Retinopathy Clinical Research Network (DRCR.net) is to develop and maintain a collaborative network to facilitate multicenter clinical research on diabetic retinopathy, diabetic macular edema and associated conditions, leading and growing causes of vision impairment and blindness in the United States and throughout the world. Its priorities include involvement of community-based practices as well as university-based centers and to collaborate with industry to facilitate investigations and opportunities otherwise not possible, but to do so in a manner consistent with the Network's dedication to academic integrity and optimal clinical trial performance. During the next funding cycle, the Network proposes to complete 5 protocols that are expected to be in progress at the time the funding period begins, initiate approximately 10 new protocols, develop and implement new methods for electronic data capture of retinal images to facilitate the conduct of diabetic retinopathy clinical trials, continue to expand the DRCR.net by soliciting the participation of new sites and encouraging the involvement of investigators who recently have completed fellowship training, continue to educate the DRCR.net investigators on the principles of clinical research, and mentor selected retina specialists to be leaders in clinical trials. The Network's Operations Center (OC) specific aims are to be responsible for the scientific oversight of protocol development. It also advises on procedures for subject enrollment;provides input to statistical analysis plans;assists the Network's Coordinating Center (CC) with protocol-specific recruitment enhancement plans and protocol- specific closeout plans;oversees members responsible for most Network manuscripts, presentations, ancillary studies, financial conflicts of interest, quality control, and protocol concepts;coordinates most Network committees, meetings, and teleconferences (e.g., setting up agendas, arranging and providing minutes for teleconferences and meetings);provides infrastructure for the Network Chair and Protocol Chairs;collaborates with outside entities (industry, FDA, foundations, other networks);certifies visual acuity examiners;and provides expertise regarding retina image acquisition and retina image analysis. Many of these activities have transferred from the CC to the office of the Network Chair since 2006. This application centralizes these activities during the next 5 years within the Network's Operations Center at Johns Hopkins.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY018817-05
Application #
8391221
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Schron, Eleanor
Project Start
2009-09-30
Project End
2013-12-31
Budget Start
2013-02-01
Budget End
2013-12-31
Support Year
5
Fiscal Year
2013
Total Cost
$154,462
Indirect Cost
$31,873
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Jampol, Lee M; Bressler, Neil M; Glassman, Adam R (2014) Revolution to a new standard treatment of diabetic macular edema. JAMA 311:2269-70
Diabetic Retinopathy Clinical Research Network Writing Committee; Bressler, Susan B; Edwards, Allison R et al. (2014) Reproducibility of spectral-domain optical coherence tomography retinal thickness measurements and conversion to equivalent time-domain metrics in diabetic macular edema. JAMA Ophthalmol 132:1113-22
Bhavsar, Abdhish R; Torres, Karisse; Glassman, Adam R et al. (2014) Evaluation of results 1 year following short-term use of ranibizumab for vitreous hemorrhage due to proliferative diabetic retinopathy. JAMA Ophthalmol 132:889-90
Diabetic Retinopathy Clinical Research Network Authors/Writing Committee; Bressler, Susan B; Baker, Carl W et al. (2014) Pilot study of individuals with diabetic macular edema undergoing cataract surgery. JAMA Ophthalmol 132:224-6
Bressler, Susan B; Almukhtar, Talat; Aiello, Lloyd P et al. (2013) Green or yellow laser treatment for diabetic macular edema: exploratory assessment within the Diabetic Retinopathy Clinical Research Network. Retina 33:2080-8
Diabetic Retinopathy Clinical Research Network Authors/Writing Committee; Baker, Carl W; Almukhtar, Talat et al. (2013) Macular edema after cataract surgery in eyes without preoperative central-involved diabetic macular edema. JAMA Ophthalmol 131:870-9
Diabetic Retinopathy Clinical Research Network* (2013) Randomized clinical trial evaluating intravitreal ranibizumab or saline for vitreous hemorrhage from proliferative diabetic retinopathy. JAMA Ophthalmol 131:283-93
Bressler, Susan B; Qin, Haijing; Melia, Michele et al. (2013) Exploratory analysis of the effect of intravitreal ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial. JAMA Ophthalmol 131:1033-40
Glassman, Adam R; Stockdale, Cynthia R; Beck, Roy W et al. (2012) Evaluation of masking study participants to intravitreal injections in a randomized clinical trial. Arch Ophthalmol 130:190-4
Sun, Jennifer K; Qin, Haijing; Aiello, Lloyd Paul et al. (2012) Evaluation of visual acuity measurements after autorefraction vs manual refraction in eyes with and without diabetic macular edema. Arch Ophthalmol 130:470-9

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