This Network Chair's Office application is one of 3 parallel applications for a five-year extension of funding for the Pediatric Eye Disease Investigator Group (PEDIG). Since its inception in 1997, PEDIG has conducted 4 protocols in strabismus, 19 protocols in amblyopia, 3 protocols in nasolacrimal duct obstruction, 2 protocols in myopia/hyperopia, and several pilot studies. By the time the funding requested in this application would begin, it is expected that 3 new protocols will have started in the current cycle a randomized trial to evaluate treatment for convergence insufficiency, a randomized trial to compare botulinum toxin with incisional surgery for esotropia, and a clinical disease registry to evaluate uveitis incidence in children with juvenile idiopathic arthritis. Despite these accomplishments, many important questions and controversies remain in pediatric eye care and strabismus. PEDIG has developed, or will be developing, clinical trials to address many of these questions. These include: (1) treatment strategies for children with a visual deficit despite maximal amblyopia treatment, (2) the effect of prescribing versus not prescribing spectacles for hyperopia in young children, (3) the best surgical and non-surgical treatments for intermittent exotropia, (4) risk factors for complications after cataract surgery, and (5) the optimal treatment for convergence insufficiency.
Specific aims for the next 5-year funding period for PEDIG are to: (1) complete the 7 protocols that are expected to be in progress at the time the funding period begins, (2) initiate 10 new protocols in common pediatric eye disorders where the current management does not have a proven rationale, (3) continue to expand the PEDIG network by soliciting the participation of new sites and investigators and encouraging the involvement of young investigators, (4) continue to educate pediatric ophthalmologists, pediatric optometrists, and clinical research coordinators on the principles of clinical trials and good clinical research practices, (5) train pediatric ophthalmologists and pediatric optometrists to be leaders in clinica trials and clinical research, and (6) develop new methods and outcome measures needed to conduct future amblyopia and strabismus trials.

Public Health Relevance

This project will have a significant impact on pediatric eye care and on quality of life of children. Much of pediatric eye care practice is based on clinical impression or limited evidence, and conducting the proposed studies will provide the high-level evidence needed to guide the management of common childhood eye diseases such as amblyopia, strabismus, cataract, intraocular inflammation, and refractive error.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10EY023198-01
Application #
8474330
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Everett, Donald F
Project Start
2014-02-01
Project End
2018-12-31
Budget Start
2014-02-01
Budget End
2014-12-31
Support Year
1
Fiscal Year
2014
Total Cost
$275,036
Indirect Cost
$99,854
Name
Duke University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Pediatric Eye Disease Investigator Group; Cotter, Susan A; Mohney, Brian G et al. (2014) A randomized trial comparing part-time patching with observation for children 3 to 10 years of age with intermittent exotropia. Ophthalmology 121:2299-310
Miller, Aaron M; Chandler, Danielle L; Repka, Michael X et al. (2014) Office probing for treatment of nasolacrimal duct obstruction in infants. J AAPOS 18:26-30
Repka, Michael X; Kraker, Raymond T; Holmes, Jonathan M et al. (2014) Atropine vs patching for treatment of moderate amblyopia: follow-up at 15 years of age of a randomized clinical trial. JAMA Ophthalmol 132:799-805