Case Western Reserve University has been a leading member of the Multicenter Network of Neonatal Intensive Care Units since 1986. Particular strengths of the Case center include: 1) a large patient population with about 4000 births and 1100 NICU admissions annually with 90% of the population contributed by inborn infants;2) 16 board certified neonatologists and 3 PhD researchers with extensive experience in NIH funded innovative clinical and basic science research;3) faculty dedicated to evidence based medicine with a proven record of collaboration and cohesive care;4)an internationally recognized follow-up program with among the highest retention rates in the Network;5)strong collaborations with our 4 board certified Maternal-Fetal Medicine colleagues;6)exceptional productivity in clinical trials within the network, and 7) demonstrated expertise, leadership and commitment to cooperative research endeavors. Our State Designated Level III perinatal Center includes 69 beds in the Neonatal Intensive Care and Step Down Units, and 18 labor and delivery suites with central fetal monitoring. In 2005 the institution will break ground on a new NICU with enhanced monitoring and an in unit operating room solely dedicated to neonatal surgery. There is a full complement of pediatric medical and surgical subspecialists together with strong nationally recognized programs in respiratory therapy, nursing, genetics, radiology, and pediatric pathology. Our follow-up program is nationally acclaimed and boasts in excess of a 90% follow-up rate. The established computerized neonatal/ perinatal and follow-up data systems have supported a number of studies. We maintain timely and accurate transmission of data to the Data Center. The experienced nurse coordinator and clinical research nurse team ensure high enrollment rates and strict compliance with protocols. Furthermore, both the Division and the Principal Investigator have shown an unusual willingness to collaborate with other scientific groups, both nationally and internationally. The Division of Neonatology and the Intensive Care Units have the physical space, the professional staff, the technology, and the patient population to qualify as one of the premier centers in the Multicenter Network of NICUs.

Public Health Relevance

To improve the health of neonates one must conduct large multicenter studies as the population at any single center is not sufficiently large to allow adequate sample sizes for important outcomes. The NRN is the most cost-effective answer to establish the infrastructure to facilitate these trials.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-A (03))
Program Officer
Raju, Tonse N
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
Schools of Medicine
United States
Zip Code
Ambalavanan, Namasivayam; Cotten, C Michael; Page, Grier P et al. (2015) Integrated genomic analyses in bronchopulmonary dysplasia. J Pediatr 166:531-7.e13
Randolph, David A; Nolen, Tracy L; Ambalavanan, Namasivayam et al. (2014) Outcomes of extremely low birthweight infants with acidosis at birth. Arch Dis Child Fetal Neonatal Ed 99:F263-8
Cotten, C Michael; Goldstein, Ricki F; McDonald, Scott A et al. (2014) Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. Pediatr Res 75:424-30
Fernandez, Erika; Watterberg, Kristi L; Faix, Roger G et al. (2014) Incidence, management, and outcomes of cardiovascular insufficiency in critically ill term and late preterm newborn infants. Am J Perinatol 31:947-56
Wadhawan, R; Oh, W; Hintz, S R et al. (2014) Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis. J Perinatol 34:64-70
Hartnett, M Elizabeth; Morrison, Margaux A; Smith, Silvia et al. (2014) Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. Invest Ophthalmol Vis Sci 55:6194-203
DeMauro, Sara B; D'Agostino, Jo Ann; Bann, Carla et al. (2014) Developmental outcomes of very preterm infants with tracheostomies. J Pediatr 164:1303-10.e2
Stark, Ann R; Carlo, Waldemar A; Vohr, Betty R et al. (2014) Death or neurodevelopmental impairment at 18 to 22 months corrected age in a randomized trial of early dexamethasone to prevent death or chronic lung disease in extremely low birth weight infants. J Pediatr 164:34-39.e2
Davis, A S; Hintz, S R; Goldstein, R F et al. (2014) Outcomes of extremely preterm infants following severe intracranial hemorrhage. J Perinatol 34:203-8
Shankaran, Seetha; Laptook, Abbot R; Pappas, Athina et al. (2014) Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. JAMA 312:2629-39

Showing the most recent 10 out of 146 publications