This Is a competitive renewal application to remain one of the cooperating study centers in the NICHD Cooperative Multicenter Neonatal Research Network. Neonatal-perinatal medicine has seen the introduction of a number of principles of management and innovative methodologies without rigorous use of the controlled observation necessary for their objective evaluation. A major problem has been the balance between assuring prompt implementation of new technologies, procedures, treatments and drugs, and adequate evaluation of their safety and efficacy. Because of the urgent demands of sick infants, care is often based upon limited knowledge of new modalities and, if the infant's condition improves, the new treatment or procedure is frequently added to the arsenal of therapies before efficacy and/or safety have been sufficiently evaluated. The NICHD Cooperative Multicenter Neonatal Research Network was established to perform some of those critical studies and to change the culture of neonatology to one of evidence-based medicine.

Public Health Relevance

The goal of this project is to improve the practice of Newborn Medicine by the rigorous performance of multicenter clinical protocols. By working together, a network of academic medical centers will investigate the safety and efficacy of treatment and management strategies used in the care of newborn infants, especially extremely preterm infants. The evidence-based results will hopefully improve clinical practice.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD027871-22
Application #
8250368
Study Section
Special Emphasis Panel (ZHD1-DSR-A (03))
Program Officer
Raju, Tonse N
Project Start
1991-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
22
Fiscal Year
2012
Total Cost
$8,169
Indirect Cost
$3,244
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Batton, B; Li, L; Newman, N S et al. (2014) Evolving blood pressure dynamics for extremely preterm infants. J Perinatol 34:301-5
Pappas, Athina; Kendrick, Douglas E; Shankaran, Seetha et al. (2014) Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates. JAMA Pediatr 168:137-47
Maheshwari, Akhil; Schelonka, Robert L; Dimmitt, Reed A et al. (2014) Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants. Pediatr Res 76:100-8
Kelleher, John; Salas, Ariel A; Bhat, Ramachandra et al. (2014) Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants. Pediatrics 134:e1369-77
Morriss Jr, Frank H; Saha, Shampa; Bell, Edward F et al. (2014) Surgery and neurodevelopmental outcome of very low-birth-weight infants. JAMA Pediatr 168:746-54
Randolph, David A; Nolen, Tracy L; Ambalavanan, Namasivayam et al. (2014) Outcomes of extremely low birthweight infants with acidosis at birth. Arch Dis Child Fetal Neonatal Ed 99:F263-8
Cotten, C Michael; Goldstein, Ricki F; McDonald, Scott A et al. (2014) Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. Pediatr Res 75:424-30
Fernandez, Erika; Watterberg, Kristi L; Faix, Roger G et al. (2014) Incidence, management, and outcomes of cardiovascular insufficiency in critically ill term and late preterm newborn infants. Am J Perinatol 31:947-56
Wadhawan, R; Oh, W; Hintz, S R et al. (2014) Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis. J Perinatol 34:64-70
Hartnett, M Elizabeth; Morrison, Margaux A; Smith, Silvia et al. (2014) Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. Invest Ophthalmol Vis Sci 55:6194-203

Showing the most recent 10 out of 137 publications