This application is a competitive renewal from the Alpert School of Medicine at Brown University for the NICHD Cooperative Multicenter Neonatal Research Network. The Neonatal Research Network has been in existence since 1986 and has the following goals: 1) to perform high quality, rigorous clinical trials for management and treatment of important morbidities that affect the outcome of term and preterm infants, 2) to ascertain temporal changes in morbidity and mortality for the highest risk infants, 3) to evaluate the epidemiology of specific morbidities using prospective observational cohort studies, 4) to evaluate new diagnostic tests that could not be done readily in a single center, and 5) to generate new hypotheses for investigation by analyzing morbidity, mortality and 18-22 month outcomes of survivors. The Brown site has been a member of the Network since 1991 and patients for Network studies are derived from a new, state of the art 80 bed Neonatal Intensive Care Unit (NICU) of Women and Infants Hospital of Rhode Island (WIH). WIH is a major teaching affiliate of the Alpert School of Medicine and is the only tertiary NICU in Southeastern New England. WIH has almost 9,000 deliveries per year (73% of the R.l. births) and coordinates a well regionalized perinatal care system which assures the care of all high risk infants in one facility. Comprehensive follow-up of infants from the NICU is conducted in the WIH Follow-up clinic. Adjoining WIH is Hasbro Children's Hospital which provides all specialized pediatric services. The Brown site has a well organized research team that includes Physicians with broad expertise in neonatal morbidities and multicenter studies, outstanding Research Nurses, and excellent follow-up to assess early childhood neurodevelopment. The Brown site has a track record of strong contributions to Network studies, minimal protocol deviations, accurate data acquisition and substantial scientific input to new protocol development. The Brown site is well positioned to continue to function as an outstanding Neonatal Research Network center and contribute to the overall goal of improving neonatal care and outcomes through rigorous research and evidence based medicine.

Public Health Relevance

Premature birth is associated with multiple morbidities which may lead to a lifetime of physical and mental disability. Rates of prematurity are rising, survival of preterm birth has plateaued and thus there are more at risk infants. Serious neonatal problems may also afflict infants born at term. This application uses a multi- center network to perform rigorous clinical research to improve the outcome of preterm and term infants.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD027904-23
Application #
8450744
Study Section
Special Emphasis Panel (ZHD1-DSR-A (03))
Program Officer
Raju, Tonse N
Project Start
1991-04-01
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
23
Fiscal Year
2013
Total Cost
$272,561
Indirect Cost
$82,300
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
Natarajan, Girija; Shankaran, Seetha; Saha, Shampa et al. (2018) Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants. J Pediatr 195:66-72.e3
Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
Lin, Betty; Ostlund, Brendan D; Conradt, Elisabeth et al. (2018) Testing the programming of temperament and psychopathology in two independent samples of children with prenatal substance exposure. Dev Psychopathol 30:1023-1040
Bajaj, Monika; Natarajan, Girija; Shankaran, Seetha et al. (2018) Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants. J Pediatr 195:33-38.e2
Vohr, Betty R; Heyne, Roy; Bann, Carla et al. (2018) High Blood Pressure at Early School Age Among Extreme Preterms. Pediatrics 142:
Natarajan, Girija; Shankaran, Seetha; Laptook, Abbot R et al. (2018) Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy. J Perinatol 38:1060-1067
Laptook, Abbot R; Bell, Edward F; Shankaran, Seetha et al. (2018) Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants. J Pediatr 192:53-59.e2
Hintz, Susan R; Vohr, Betty R; Bann, Carla M et al. (2018) Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics 142:
Vohr, Betty R; Heyne, Roy; Bann, Carla M et al. (2018) Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr 200:132-139.e3
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201

Showing the most recent 10 out of 300 publications